World's Largest Resource for Cardiovascular Perfusion

Perfusion StaffingPerfusion Staffing
   +1 888-499-5672Login
Perfusion NewswireMain ZoneMobile ZonePerfusion ZoneTwenty Years of Vasoplegic Syndrome Treatment in Heart Surgery. Methylene Blue Revised

Twenty Years of Vasoplegic Syndrome Treatment in Heart Surgery. Methylene Blue Revised

Main Zone, Mobile Zone, Perfusion Zone
1 min read

Objective: This study was conducted to reassess the concepts established over the past 20 years, in particular in the last 5 years, about the use of methylene blue in the treatment of vasoplegic syndrome in cardiac surgery.

Methods: A wide literature review was carried out using the data extracted from: MEDLINE, SCOPUS and ISI WEB OF SCIENCE.

Results: The reassessed and reaffirmed concepts were 1) MB is safe in the recommended doses (the lethal dose is 40 mg/kg); 2) MB does not cause endothelial dysfunction; 3) The MB effect appears in cases of NO up-regulation; 4) MB is not a vasoconstrictor, by blocking the cGMP pathway it releases the cAMP pathway, facilitating the norepinephrine vasoconstrictor effect; 5) The most used dosage is 2 mg/kg as IV bolus, followed by the same continuous infusion because plasma concentrations sharply decrease in the first 40 minutes; and 6) There is a possible “window of opportunity” for MB’s effectiveness. In the last five years, major challenges were: 1) Observations about side effects; 2) The need for prophylactic and therapeutic guidelines, and; 3) The need for the establishment of the MB therapeutic window in humans.

Conclusion: MB action to treat vasoplegic syndrome is time-dependent. Therefore, the great challenge is the need, for the establishment the MB therapeutic window in humans. This would be the first step towards a systematic guideline to be followed by possible multicenter studies.

You may also like

Main Zone, Mobile Zone, Perfusion Zone

Antegrade and RetroGrade Perfusion in Minimally Invasive Mitral Valve Surgery with Transthoracic Aortic Clamping: A Single-Institution Experience with 1632 Patients over 12 Years

The aim of the present study was to evaluate the impact of a retrograde arterial perfusion (RAP) strategy versus an antegrade arterial perfusion (AAP) strategy in a consecutive, large cohort of patients who underwent minimally invasive mitral valve surgery with transthoracic aortic clamping through a right minithoracotomy.

1 min read
Education, Sanibel Symposium

The Sanibel Symposium Internship Program: Shaping the Future of Perfusion

The Sanibel Internship Program is more than just an internship—it is a gateway to the world of perfusion. This unique opportunity allows students to engage with top professionals, gain invaluable hands-on experience, and stay at the forefront of advancements in the field. As part of one of the most prestigious perfusion conferences, interns not only observe but actively contribute, building connections and skills that will shape their future careers.

6 min read
Join TodayJoin Today