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Study Protocol: Nitric Oxide During Cardiopulmonary Bypass to Improve Recovery in Infants With Congenital Heart Defects (NITRIC Trial): A Randomised Controlled Trial
Congenital heart disease (CHD) is a major cause of infant mortality. Many infants with CHD require corrective surgery with most operations requiring cardiopulmonary bypass (CPB). CPB triggers a systemic inflammatory response which is associated with low cardiac output syndrome (LCOS), postoperative morbidity and mortality. Delivery of nitric oxide (NO) into CPB circuits can provide myocardial protection and reduce bypass-induced inflammation, leading to less LCOS and improved recovery.
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Sodium Bicarbonate Therapy for the Prevention of Contrast-Induced Acute Kidney Injury – A Systematic Review and Meta-Analysis
This updated meta-analysis demonstrates that sodium bicarbonate-based hydration is superior to sodium chloride in preventing CI-AKI of patients undergoing exposure to iodinated contrast media.
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Factors Associated with Acute Kidney Injury and Mortality During Cardiac Surgery
A history of hypertension was predictive of the development of CSA-AKI, and preoperative eGFR was an independent predictor of mortality in this cohort. Both factors are modifiable.
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