The Lower Threshold of Hypothermic Oxygen Delivery to Prevent Neonatal Acute Kidney Injury

Background

Oxygen delivery during cardiopulmonary bypass (CPB) is closely related to postoperative acute kidney injury (AKI). The value of critical indexed oxygen delivery (DO₂i) is a key indicator to reflect oxygen supply in cardiovascular surgery. However, the target DO₂i value for neonates undergoing hypothermic CPB remains unclear.

Methods

One hundred and twenty-six consecutive newborns (≤28 days) undergoing arterial switch operations were retrospectively divided into two groups according to AKI occurrence. Baseline characteristics, intraoperative variables, and clinical outcomes were collected. Multivariate logistic regression analysis and receiver-operating characteristic curve were performed to investigate the association between DO₂i and AKI.

Results

Neonates in the no-AKI group (n = 67) had significantly higher nadir bypass flow and DO₂i during the hypothermic phase compared with the AKI group (n = 59). AKI group had remarkably higher incidences of hepatic dysfunction and peritoneal dialysis requirement compared with newborns without AKI. Mixed venous oxygen saturation (SvO₂) was comparable between the two groups. Base excess (BE)(P = 0.011) value during the hypothermic phase of the AKI group was higher than the no-AKI group. Multivariate analysis showed that hypothermic DO₂i was negatively associated with AKI. The cut-off value of hypothermic DO₂i was 269 mL min⁻¹ m⁻².

Conclusions

The importance of hypothermic DO₂i should be highlighted, even when SvO₂ was satisfactory. A lower threshold of DO₂i > 269 mL min⁻¹ m⁻² may help protect neonates from the risk of postoperative AKI.