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Updating an Empirically Based Tool for Analyzing Congenital Heart Surgery Mortality
The updated STAT metrics reflect contemporary practice and outcomes. New empirically based STAT 2020 Scores and Category designations are assigned to a larger set of procedure codes, while accounting for risk associated with multiple component operations. Updating STAT metrics based on contemporary outcomes facilitates accurate assessment of case mix.
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Modulating the Bioactivity of Nitric Oxide as a Therapeutic Strategy in Cardiac Surgery
Perspectives for modulation of endothelial function using NO-mediated mechanisms are discussed. Some of these strategies may provide important therapeutic benefits for human cardiovascular interventions.
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Mesenchymal Stem Cell Therapy in Osteoarthritis: Advanced Tissue Repair or Intervention with Smouldering Synovial Activation
Desando and co-workers report in Arthritis Research & Therapy that intra-articular delivery of adipose-derived stem cells attenuates progression of synovial activation and joint destruction in osteoarthritis in an experimental rabbit model. Clinical studies are warranted to see whether this approach might be a novel way to combat development of joint destruction in inflammatory subtypes of osteoarthritis.
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