By using an established rat model of CPB that does not display neuronal loss, we examined behavioral and structural effects of CPB at 6 months postsurgery. Persistent deficits in performance on a complex behavioral task and sustained activation of macrophages/microglia were observed with no evidence of neuronal loss.
The International Collaboration on Endocarditis-PLUS (ICE-PLUS) is a prospective cohort of consecutively enrolled patients with definite IE from 29 centers in 16 countries.
