Prolonged Cardiopulmonary Bypass is Associated With Endothelial Glycocalyx Degradation

Epidemiology of Acute Kidney Injury After Neonatal Cardiac Surgery: A Report From the Multicenter Neonatal and Pediatric Heart and Renal Outcomes Network

Cardiac surgery–associated acute kidney injury occurs frequently after neonatal cardiac surgery in both cardiopulmonary bypass and noncardiopulmonary bypass patients. Rates vary significantly across hospitals. Only stage 3 cardiac surgery–associated acute kidney injury is associated with mortality. Cardiac surgery–associated acute kidney injury was not associated with any other outcomes. Kidney Disease Improving Global Outcomes criteria may not precisely define a clinically meaningful renal injury phenotype in this population.

Diagnosis and Management of Heparin-Induced Thrombocytopenia

HIT is a clinical-biological syndrome induced by IgG isotype antibodies, which almost always recognise heparin-modified platelet factor 4 (PF4/H), with intense platelet activation associated with explosive thrombin generation that can lead to venous and/or arterial thrombosis.