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This review analyzes the history, physiology, techniques of DHCA, as well as other alternative strategies like selective cerebral perfusion and presents the current available evidence.
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The Challenge of Estimating Treatment Effects in Cardiac Surgery
For several decades the cardiac surgery community has relied on observational comparative studies, often due to the perception than randomized trials are too challenging and complex. We have described how only less than 10% of the available evidence on the 10 most commonly performed surgical procedures comes from randomized trials and how the number of published cardiac surgery trials has decreased significantly over the course of the last 20 years.
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What is the Role of Different Cardioplegic Solutions in the Perioperative Immune Response During Cardiac Surgery?
We tested the hypothesis that surgical trauma is the main factor determining the perioperative immune response and that, therefore, the use of different cardioplegic solutions, as previously discussed, did not influence the perioperative immune response.
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