Perfusion Life: The InElegant Hack

Safety and Efficacy of Prothrombin Complex Concentrate as First-Line Treatment in Bleeding after Cardiac Surgery

Bleeding after cardiac surgery requiring surgical reexploration and blood component transfusion is associated with increased morbidity and mortality. Although prothrombin complex concentrate (PCC) has been used satisfactorily in bleeding disorders, studies on its efficacy and safety after cardiopulmonary bypass are limited.

Augmentation of Thrombin Generation in Neonates Undergoing Cardiopulmonary Bypass

We compared recombinant activated factor VII (rFVIIa) with three-factor prothrombin complex concentrate (3F-PCC) for the ability to augment thrombin generation (TG) in neonatal plasma after cardiopulmonary bypass (CPB).