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Heparin Resistance — Clinical Perspectives and Management Strategies
Heparin resistance is suspected when more heparin than usual is needed to achieve a therapeutic range of activated partial-thromboplastin time. Management may include increasing the heparin dose, supplementing antithrombin III levels, and using direct thrombin inhibitors.
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Factors Influencing Activated Clotting Time Following Heparin Administration for the Initiation of Cardiopulmonary Bypass
Old age, heart failure, and lower platelet counts affected heparin activity. The dose of heparin should be considered in those patients to reach the target ACT.
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