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Optimal Protamine Dosing after Cardiopulmonary Bypass: The PRODOSE Adaptive Randomised Controlled Trial
Using a mathematical model to guide protamine dosing in patients following CPB improved TEG r-time and reduced the dose administered relative to a fixed ratio. No differences were detected in postoperative mediastinal/pleural drainage or red blood cell transfusion requirement in our cohort of low-risk patients.
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Activation of Platelet-Rich Plasma Using Soluble Type I Collagen
In this work, our hypothesis was that soluble type I collagen would be as effective as bovine thrombin in causing clotting of the PRP and stimulating growth factor release from the platelets and granulocytes.
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ECMO Circuit Change
Common reasons for replacing the ECMO circuit include the buildup of blood clots, with or without an increase in Delta P. This condition can be linked to the activation of the coagulation process and inflammation, such as a rise in D-Dimer levels and a decrease in fibrinogen levels (less than 2).
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