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Effect of High-Dose Ulinastatin on the Cardiopulmonary Bypass-Induced Inflammatory Response in Patients Undergoing Open-Heart Surgery
Therefore, different routes of UTI administration may restrict its effects. Further studies are needed to evaluate the most effective route of administering the total dose of UTI used in this study.
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Post-Reperfusion Changes of Monocyte Function in Coronary Blood After Extracorporeal Circulation
Knowledge of mechanisms underlying monocyte functional modulation in coronary blood may be useful to develop protective interventions that can limit ischemia/reperfusion injury.
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The Association of Matrix Metalloproteinases With Acute Kidney Injury Following CPB-Supported Cardiac Surgery
Although the pilot study may have limitations, it has demonstrated that the serum and urine levels of activity of MMP-2 and MMP-9 are associated with the clinical endpoint of AKI and appear to have earlier rising levels as compared with those of serum creatinine. Furthermore, in depth, exploration is underway with a larger sample size to attempt validation of the analytical performance and reproducibility of the assay for MMP-2 and MMP-9 to aid in earlier diagnosis of AKI following CPB-supported cardiac surgery.
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