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Postoperative Goal-Directed Therapy and Development of Acute Kidney Injury Following Major Elective Noncardiac Surgery: Post-Hoc Analysis of POM-O Randomized Controlled Trial
The role of goal-directed therapy (GDT) in preventing creatinine rise following noncardiac surgery is unclear. We performed a post-hoc analysis of a randomized controlled trial to assess the relationship between postoperative optimization of oxygen delivery and development of acute kidney injury (AKI)/creatinine rise following noncardiac surgery.
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The Risk Associated with Aprotinin in Cardiac Surgery
In this observational study involving 4374 patients undergoing revascularization, we prospectively assessed three agents (aprotinin [1295 patients], aminocaproic acid [883], and tranexamic acid [822]) as compared with no agent (1374 patients) with regard to serious outcomes by propensity and multivariable methods.
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