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Study Protocol: Nitric Oxide During Cardiopulmonary Bypass to Improve Recovery in Infants With Congenital Heart Defects (NITRIC Trial): A Randomised Controlled Trial
Congenital heart disease (CHD) is a major cause of infant mortality. Many infants with CHD require corrective surgery with most operations requiring cardiopulmonary bypass (CPB). CPB triggers a systemic inflammatory response which is associated with low cardiac output syndrome (LCOS), postoperative morbidity and mortality. Delivery of nitric oxide (NO) into CPB circuits can provide myocardial protection and reduce bypass-induced inflammation, leading to less LCOS and improved recovery.
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Assessing Efficacy of CytoSorb Haemoadsorber for Prevention of Organ Dysfunction in Cardiac Surgery Patients with Infective Endocarditis: REMOVE-Protocol for Randomised Controlled Trial
The REMOVE study is an interventional randomised controlled multicenter trial with a group sequential (Pocock) design for assessing efficacy of CytoSorb in patients undergoing cardiac surgery for IE.
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Perfusion Guidelines: Neurological, Temperature, Renal, Inflammation (EP Video)
Dr. Robert Baker and David Fitzgerald discusses current evidence-based perfusion guidelines on a few different subjects (78:10 minutes).
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