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Jordan Voss discusses antithrombin 3 (AT3) administration during ECLS cases (15:30 minutes).
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Shear Stress Associated with Cardiopulmonary Bypass Induces Expression of Inflammatory Cytokines and Necroptosis In Monocytes
Our study identifies a shear-stress modulated molecular mechanism that drives systemic inflammation in pediatric CPB patients. These are also the first data to demonstrate that shear-stress causes necroptosis. Finally, we observe that calcium and TNFα signaling are novel targets to ameliorate post-CPB inflammation.
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Reduced Systemic Nitric Oxide Bioavailability Parallels Microvascular Endothelial Dysfunction during Cardiopulmonary Bypass
The impairment of microvascular endothelial function during CPB in cardiac surgery for the correction of congenital heart defects appears to be related to a reduced systemic bioavailability of NO, resulting from the inflammatory and pro-oxidative response typical of this surgical procedure.
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