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Surviving and Thriving 1 Year After Cardiac Surgery: Frailty and Delirium Matter
Preoperative frailty alone did not negatively affect cardiac surgery patients’ functional outcomes up to 1 year, but coexisting frailty and POD led to substantial loss of independence on 3 to 4 ADLs and a 30.2-fold higher likelihood of dying 1 year after surgery. Because frailty led to a 4.9-fold increase in POD risk, frailty may serve as a presurgical screen to identify patients who would likely benefit from delirium prevention and functional recovery programs to maximize 1-year postsurgical outcomes.
Precondition of Sevoflurane Upregulates TIMP3 Expression to Alleviate Myocardial Ischemia/Reperfusion Injury
Sef preconditioning ameliorated myocardial I/R injury by modulating MAPKs pathway activity via upregulating TIMP3.