Platelet Concentrate Injection Improves Achilles Tendon Repair in Rats
BACKGROUND: Blood platelets release a cocktail of growth factors when activated, some of which are thought to initiate and stimulate repair. EXPERIMENT […]
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Diagnosis and Management of Circulatory Arrest in Pediatric Ventricular Assist Device Patients: Presentation of Two Cases and Suggested Guidelines
Pediatric patients supported by ventricular assist devices (VADs) are becoming more common. No guidelines exist to provide an approach to diagnosis or management of circulatory arrest in these patients. We present two case reports of apparent circulatory arrest in pediatric VAD-supported patients at our institution.
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Sequestration of Dexmedetomidine in Ex Vivo Cardiopulmonary Bypass Circuits
The percent sequestration of DEX was lower in CPB circuits at lower DEX doses compared to higher doses. A combination of DEX initial loading dose and continuous infusion resulted in steady concentrations of DEX over 4 hours. At therapeutically relevant concentrations of DEX (485–1,013 pg/ml), lower sequestration was observed in ex vivo CPB circuits compared to higher doses. The sequestration of DEX to circuits should be considered to achieve the optimal concentration of DEX during CPB surgery.
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