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Antifibrinolytic Drugs for the Prevention of Bleeding in Pediatric Cardiac Surgery on Cardiopulmonary Bypass: A Systematic Review and Meta-analysis
The available data demonstrate efficacy for all 3 antifibrinolytic drugs. Therefore, the agent with the most favorable safety profile should be used. As sufficient data are lacking, large comparative trials are warranted to assess the relative safety and appropriate dosing regimens in pediatrics.
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Coronary Artery Bypass Grafting after Aprotinin: Are We Doing Better?
Accordingly, the usage of aprotinin should be reconsidered for treatment among cohorts of low-risk cardiac patients.
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