Engineering Blood Outgrowth Endothelial Cells to Optimize Endothelial Nitric Oxide Synthase and Extracellular Matrix Production for Coating of Blood Contacting Surfaces
Taken together, our findings demonstrate that cell-ECM interactions are fundamental to the regulation of eNOS in BOECs and suggest that disruption of key intracellular pathways (such as ROCK) may be necessary to enhance functional activity of an endothelialized surface.