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Coronary atherosclerosis begins at a young age. Indeed, atherosclerotic lesions are present in one of six United States teenagers. These are the […]
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Effect of Mean Arterial Pressure, Haemoglobin and Blood Transfusion During Cardiopulmonary Bypass on Post-Operative Acute Kidney Injury
Acute kidney injury (AKI) after cardiac surgery is a common and serious condition carrying significant costs
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A Novel Antidote-Controlled Anticoagulant Reduces Thrombin Generation and Inflammation and Improves Cardiac Function in Cardiopulmonary Bypass Surgery
Here we demonstrate that an anticoagulant aptamer-antidote pair targeting factor IXa can replace heparin and protamine in a porcine CPB model and also limit the adverse effects on thrombin generation, inflammation, and cardiac physiology associated with heparin and protamine use.
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