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Combination of Acute Preoperative Plateletpheresis, Cell Salvage, and Aprotinin Minimizes Blood Loss and Requirement During Cardiac Surgery
In this prospective randomized clinical study, the efficacy of these combined approaches on reducing blood loss and transfusion requirements was evaluated.
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Controlling Reperfusion Injury With Controlled Reperfusion: Historical Perspectives and New Paradigms
This review article first provides a basic overview of the primary pathways to cell death that have the potential to be addressed by various forms of controlled reperfusion, including no-reflow phenomenon, ion imbalances (particularly calcium overload), and oxidative stress. Descriptions of various controlled reperfusion approaches are described, along with summaries of both mechanistic and outcome-oriented studies at the pre-clinical and clinical phases.
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