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Hemodilution (hemoglobin, 6 g/dL) increased cerebral infarct volume and worsened outcome after focal cerebral ischemia during cardiopulmonary bypass in rats; this suggests that excessive hemodilution may increase the risk of cardiac surgery-related stroke.
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Hydroxyethyl Starch on Kidney and Haemostatic Function in Cardiac Surgical Patients: Is A Non-Inferiority Study Design Appropriate for This Setting?
In light of the existing concerns on HES use, this study leaves several unanswered questions: how should patients be informed when they are asked to participate in a clinical trial that may randomise them to receive HES? How can a prestigious research group consider it appropriate to adopt a ’non‐inferiority’ study design to evaluate the safety profile of a controversial drug such as HES, when any proven beneficial effects (if there are any) remain unanswered?
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Ex-Vivo Single Lung Perfusion Techniques: Expanding the Perfusionist Role during Lung Transplantation (EP Video)
George Justison discusses expanding the perfusionist's role during lung transplation procedures (12:41 minutes).
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