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The Clinical Utility of Bivalirudin in Patients with cCoronary Artery Disease
We present the major studies that have brought bivalirudin to the forefront of coronary artery disease, specifically coronary interventional procedures.
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Toll-like Receptor 9 and the Inflammatory Response to Surgical Trauma and Cardiopulmonary Bypass
CPB, surgical trauma and ischemic perfusion injury trigger the release of circulating mtDNA that activates TLR-9, in turn stimulating a release of IL-6. Therefore, TLR-9 antagonists may attenuate this response and may provide a future therapeutic target whereby the systemic inflammatory response to cardiac surgery may be manipulated to improve clinical outcomes.
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