Cryoprecipitate v1.0

Cryoprecipitate

Cryoprecipitate contains 2 or more times the concentration of fibrinogen contained in plasma as well as increased levels of factor V and factor VIII.   Each unit however, contains only 50 ml, thus conceivably requiring several units of cryoprecipitate to be administered in order to achieve target ranges (>150 mg/dl) for depleted fibrinogen levels.  This represents exposure to multiple donors and implies an increased risk to the recipient.

Woodman RC, Harker LA. Bleeding Complications Associated with Cardiopulmonary Bypass. Blood. 1990;76:1680-97,