World's Largest Resource for Cardiovascular Perfusion

Perfusion StaffingPerfusion Staffing
   +1 888-499-5672Login
Perfusion NewswireCircuit SurfersCommon Pathway (Coagulation)

Common Pathway (Coagulation)

Circuit Surfers, Education

The endpoint of activity for both the extrinsic and intrinsic pathways for coagulation is the activation of factor X.  Reactions beyond this point are common to both pathways, and involves the combining of activated factor X with procoagulants (factor II, factor V, calcium ions, and platelet phospholipids) to form a prothrombinase complex.  This complex catalyzes the conversion of circulating prothrombin into thrombin, which in turn converts circulating fibrinogen into insoluble fibrin.  The coagulation process is terminated by the stabilization of fibrin via the activation of factor XIII.

 

Speiss BD. Perioperative coagulation concerns: Function, monitoring, and therapy. Clinical Anesthesia Updates. 1993;4:1-14

Leave a Reply

You may also like
ECMO Zone, Perfusion Zone, Tiny Perfusion Letter

International Survey of Neuromonitoring and Neurodevelopmental Outcome in Children and Adults Supported on Extracorporeal Membrane Oxygenation in Europe

This survey demonstrated significant variability in the use of different neuromonitoring modalities during and after ECMO. The perceived importance of neuromonitoring and follow-up was noted to be very high with agreement for a longitudinal structured follow-up programme, particularly in paediatric patients. Scientific society endorsed guidelines and minimum standards should be developed to inform local protocols.

Join TodayJoin Today