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The Cost of Innovation and Evidence in Cardiac Surgery
This review summarizes a systematic analysis of 216 randomized trials of cardiovascular interventions performed during 2008–2019, according to the source of trial funding.
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Antifibrinolytic Drugs for the Prevention of Bleeding in Pediatric Cardiac Surgery on Cardiopulmonary Bypass: A Systematic Review and Meta-analysis
The available data demonstrate efficacy for all 3 antifibrinolytic drugs. Therefore, the agent with the most favorable safety profile should be used. As sufficient data are lacking, large comparative trials are warranted to assess the relative safety and appropriate dosing regimens in pediatrics.
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The Relationship Between Intraoperative Blood Transfusion and Postoperative Systemic Inflammatory Response Syndrome
Previous observations suggest that intraoperative blood transfusion (IBT) is a risk factor for adverse postoperative outcomes. IBT alters immune function and may predispose to systemic inflammatory response syndrome (SIRS).
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