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The Orpheus Perfusion Simulator In Industry (Video)
Ben Komorowski discusses the Orpheus simulator applications for industry (11.45 minutes).
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Bivalirudin for Alternative Anticoagulation in Extracorporeal Membrane Oxygenation
Extracorporeal membrane oxygenation (ECMO) offers therapeutic options in refractory respiratory and/or cardiac failure. Systemic anticoagulation with heparin is routinely administered. However, in patients with heparin-induced thrombocytopenia or heparin resistance, the direct thrombin inhibitor bivalirudin is a valid option and has been increasingly used for ECMO anticoagulation. We aimed at evaluating its safety and its optimal dosing for ECMO.
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Heparin Resistance — Clinical Perspectives and Management Strategies
Heparin resistance is suspected when more heparin than usual is needed to achieve a therapeutic range of activated partial-thromboplastin time. Management may include increasing the heparin dose, supplementing antithrombin III levels, and using direct thrombin inhibitors.
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