Exposure–Response Relationship of Tranexamic Acid in Cardiac Surgery: A Model-based Meta-analysis
In cardiopulmonary bypass surgery, low-dose tranexamic acid seems to be an appropriate regimen for reducing bleeding outcomes. This meta-analysis has to be interpreted with caution because the results are observational and dependent on the lack of bias of the predicted tranexamic acid exposures and the quality of the included studies.
Impact of Corticosteroids on Cardiopulmonary Bypass Induced Inflammation in Children:A Meta-Analysis
CS were found to have a favorable impact on postoperative fluid balance and may be associated with shortening the duration of mechanical ventilation. While CS had no impact on mortality, they may be beneficial, particularly in neonates and those undergoing high complexity surgery.
Effects of Remote Ischemic Preconditioning on Platelet Activation and Reactivity in Patients Undergoing Cardiac Surgery Using Cardiopulmonary Bypass: A Randomized Controlled Trial
RIPC did not alter platelet activation and reactivity during CPB in patients undergoing cardiac surgery.
Artificial Lungs–Where Are We Going with The Lung Replacement Therapy?
Recent progress in artificial lung technologies includes continued advances in both engineering and biology. The final goal is to achieve a truly implantable and durable artificial lung that is applicable to destination therapy.
Successful Use of An Automated Proning System to Achieve Prone Positioning in A Patient with Severe ARDS Requiring Veno-Venous ECMO
To our knowledge, this is the first description in the literature of using an automated proning system with an ECMO circuit in place. This report describes the technique we used to safely perform axial rotations for two days with fewer providers required than manual proning.
A Review on Extracorporeal Membrane Oxygenation and Kidney Injury
The pathophysiology of AKI in ECMO is multifactorial, and includes ischaemia, RBCs breakdown, comorbidity, conversion of zymogen form of pro‐inflammatory mediators, structural alteration of the kidney, coadministration of nephrotoxic drugs, coagulation abnormality, and oxidative stress.
Tranexamic Acid and Convulsive Seizures After Isolated Coronary Artery Bypass Surgery: The Role of Cardiopulmonary Bypass and Renal Function
Our data in patients undergoing isolated CABG indicate no significant effect on CS risk by use of CPB when TXA doses of up to ∼2 g are given. However, caution regarding TXA administration is necessary in patients with renal impairment.
American Society of ExtraCorporeal Technology: Development of Standards and Guidelines for Pediatric and Congenital Perfusion Practice (2019)
The Standards and Guidelines for Pediatric and Congenital Perfusion Practice is an essential tool for pediatric perfusionists and serves as the backbone for institutionally based protocols, promotes improved decision-making, and identifies opportunities for future research and collaboration with other disciplines.
Biological Effects of The Oxygen Molecule in Critically Ill Patients
Given the biological effects of oxygen molecules, although the optimal target levels remain controversial, unnecessary oxygen administration should be avoided, and exposure to hyperoxemia should be minimized in critically ill patients.
High Versus Low Blood Pressure Targets for Cardiac Surgery with Cardiopulmonary Bypass
We plan to extract study data, format our comparisons in data tables and prepare a 'Summary of findings' table before writing the results and conclusions of our review.
Pitfalls of Commonly Used Anticoagulation Monitoring Techniques in Antiphospholipid Syndrome During Cardiopulmonary Bypass
Herein the authors report a case of a patient with APS undergoing PTE that highlights several limitations of the available coagulation monitoring strategies. The patient provided written consent for publication of the details of the case.
Incidental Detection of Factor XII Deficiency Following Coronary Artery Bypass Grafting
In conclusion, fXII deficiency is a very rare disorder that is manifested by elevated aPTT and ACT values. Timely diagnosis, adequate perioperative coagulation monitoring, and postoperative prophylaxis with LMWH will minimize the occurrence of complications.