Cell-Cycle Arrest Biomarkers Usefulness for Cardiac Surgery-Related Acute Kidney Injury in Neonates and Infants
These findings question the usefulness of (TIMP-1) × (IGFBP-7) for the prediction of cardiac surgery-related acute kidney injury in neonates and infants when measured within 3 hours of cardiopulmonary bypass.
Increased Circulating Levels of Neutrophil Extracellular Traps During Cardiopulmonary Bypass
Circulating NETs measurements increases during cardiac surgery with postsurgical levels proportional to CPB duration. The clinical significance of NETs production during cardiac surgery should be further investigated.
The Relationship Between Neurocognitive Decline and the Heart‐Lung Machine
Further research, comparing on‐pump and off‐pump cohorts and involving intensive screening of preoperative cognitive decline, is indicated to elucidate the true neurocognitive consequences of the heart‐lung machine.
Sourcing Personal Protective Equipment During the COVID-19 Pandemic
An increase in PPE supply in response to this new demand will require a large increase in PPE manufacturing, a process that will take time many health care systems do not have, given the rapid increase in ill COVID-19 patients.
Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)
Myocardial injury is significantly associated with fatal outcome of COVID-19, while the prognosis of patients with underlying CVD but without myocardial injury is relatively favorable.
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
In this preliminary uncontrolled case series of 5 critically ill patients with COVID-19 and ARDS, administration of convalescent plasma containing neutralizing antibody was followed by improvement in their clinical status.
Outcome Impact of Different Tranexamic Acid Regimens in Cardiac Surgery with Cardiopulmonary Bypass (OPTIMAL): Rationale, Design, and Study Protocol of a Multicenter Randomized Controlled Trial
The study is designed to identify a TxA dose with maximal efficacy and minimal complications. We hypothesize that the high dose has superior efficacy and noninferior safety to the low dose.
Update on Extracorporeal Carbon Dioxide Removal: a Comprehensive Review on Principles, Indications, Efficiency, and Complications
Extracorporeal carbon dioxide removal means the removal of carbon dioxide from the blood across a gas exchange membrane without substantially improving oxygenation.
Large-Vessel Occlusion Stroke after Cardiothoracic Surgery: Expanding Time Windows Offer New Salvage Opportunities
LVO complicates a small proportion of patients after CTS and may be more likely with prolonged aortic crossclamp and cardiac bypass times.
Are We Close to Bioengineering a Human-Sized, Functional Heart?
The model ventricles can be evaluated with the same assays used in animal models and in clinical settings.
Influence of a High-Intensity Staffing Model in a Cardiac Surgery Intensive Care Unit on Postoperative Clinical Outcomes
High-intensity staffing model during daytime hours by cardiac surgery intensivists significantly improved ICU-related outcomes. However, high-intensity staffing did not affect early mortality after cardiac surgery.
Results from an Enhanced Recovery Program for Cardiac Surgery
There is value in developing phase-specific enhanced recovery programs guidelines, which improve rates of early extubation and affect the duration of stay after cardiac surgery.