Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19)
The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new recommendations in further releases of these guidelines.
Testing an Old Therapy Against a New Disease: Convalescent Plasma for COVID-19
For now—and possibly the next 18 to 24 months, convalescent plasma, despite supply issues and questions about efficacy and who is most likely to benefit from treatment, remains the only off-the-shelf therapy for COVID-19.
Out-of-Hospital Cardiac Arrest during the Covid-19 Outbreak in Italy
The cumulative incidence of out-of-hospital cardiac arrest in 2020 was strongly associated with the cumulative incidence of Covid-19, and the increase in the number of cases of out-of-hospital cardiac arrest over the number in 2019 followed the time course of the Covid-19 outbreak
The Essential Role of Patient Blood Management in a Pandemic: A Call for Action
This multinational and diverse group of authors issue this “Call to Action” underscoring “The Essential Role of Patient Blood Management in the Management of Pandemics” and urging all stakeholders and providers to implement the practical and common-sense principles of PBM and its multi-professional and multimodality approaches.
Patient Blood Management During the COVID‐19 Pandemic ‐ a Narrative Review
This review considers the impact of the COVID‐19 pandemic on the blood supply and specifies important aspects of donor management.
A Narrative Review of Antithrombin Use During Veno-Venous Extracorporeal Membrane Oxygenation in Adults: Rationale, Current Use, Effects on Anticoagulation, and Outcomes
Antithrombin use in veno-venous extracorporeal membrane oxygenation should be investigated on the threshold for supplementation, dose, and time of administration.
Antifibrinolytics and Cardiac Surgery: The Past, the Present, and the Future
Pharmacological as well as nonpharmacological strategies have been used to reduce blood loss. Among the pharmacological approaches, antifibrinolytic drugs are the mainstay.
Coagulation Test Changes Associated with Acute Normovolemic Hemodilution in Cardiac Surgery
In patients undergoing cardiac surgery requiring CPB, ANH results in significant improvements of aPTT, fibrinogen and hemoglobin values; however, the true clinical significance is questionable. In the absence of ongoing surgical bleeding, there appears to be normalization of coagulation tests (excluding fibrinogen) following CPB.
Del Nido Cardioplegia in Coronary Surgery: a Propensity-Matched Analysis
In this large cohort of CABG patients, DNC was shown as a safe alternative to CC and was associated with lower postoperative dysrhythmia and infection rates.
Hyperoxemia and Excess Oxygen Use in Early Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study
Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort.
Biomarker-Guided Implementation of the KDIGO Guidelines to Reduce the Occurrence of Acute Kidney Injury in Patients after Cardiac Surgery (PrevAKI-multicentre): Protocol for a Multicentre, Observational Study Followed by Randomised Controlled Feasibility Trial
The purpose of the observational survey is to explore the adherence to the KDIGO recommendations in routine clinical practice. The second phase is a randomised controlled trial. The objective is to investigate whether the trial protocol is implementable in a large multicentre, multinational setting.
Preconditioning Strategies to Prevent Acute Kidney Injury
In this review, the most attractive strategies and the current mechanistic concepts are introduced and discussed. Furthermore, we present clinical trials evaluating the feasibility of preconditioning in the clinical setting.