Engineered Protein Cages for Selective Heparin Encapsulation
The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.
Health System Needs to Establish Cardiac Surgery Centers
Here, we describe the workforce, infrastructure, financial, and political needs and considerations from a health systems perspective to establish a cardiac surgery center.
Neurological Outcome After Minimally Invasive Coronary Artery Bypass Surgery (NOMICS): An Observational Prospective Cohort Study
The incidence of poor neurocognitive outcome, including stroke, POCD and postoperative ICU delirium until three months after Endo-CABG is low and comparable with PCI.
Ten Years of The Helsinki Declaration on Patient Safety in Anaesthesiology: An Expert Opinion on Peri-Operative Safety Aspects
With this publication we hope to further stimulate implementation of the Helsinki Declaration on Patient Safety in Anaesthesiology, as well as initiating relevant research in the future.
Blood Oxygenation Using Fluoropolymer-Based Artificial Lung Membranes
The blood oxygenation performance was assessed using animal sheep blood, and the fabricated fluoropolymer membranes showed competitive performance to that of commercial polyolefin membranes without any detectable hemolysis. The data also confirmed that the bottleneck in the blood oxygenation performance was not the membrane permeance but rather the rate of mass transfer in the blood phase, highlighting the importance of efficient module design.
Hyperoxia During Cardiopulmonary Bypass Is Associated With Mortality in Infants Undergoing Cardiac Surgery
Hyperoxia during cardiopulmonary bypass was an independent risk factor for mortality and may be a modifiable risk factor. Furthermore, hyperoxia during cardiopulmonary bypass was associated with four-fold greater odds of mortality within 30 days of surgery.
ECMELLA: Successful Rescue Cardiopulmonary Support in Post-Coronary Artery Bypass Graft Cardiogenic Shock with Cardiac Arrest-Case Report
Although there is limited evidence of the benefit of a combined use of mechanical support (VA-ECMO with other mechanical devices) in the management of cardiogenic shock and cardiac arrest following CABG surgery, there seems to be a lower mortality with this approach, and possibly more favourable neurological outcomes. Further research is needed to elucidate the advantages of Impella vs. intra-aortic balloon pump combined with VA-ECMO in such patients.
A New Anticoagulation Strategy Using Recombinant Human Thrombomodulin in Patients on Veno-Venous Extracorporeal Membrane Oxygenation: A Retrospective Study
In this retrospective study, we analyzed 15 patients with severe respiratory failure who were administered rhTM as an anticoagulant during VV-ECMO and found that anticoagulation therapy with rhTM is maybe a feasible option which allows for effective and safe VV-ECMO.
Concurrent Use of Renal Replacement Therapy during Extracorporeal Membrane Oxygenation Support: A Systematic Review and Meta-Analysis
RRT on ECMO was associated with higher mortality rates and a longer ICU/hospital stay compared to those without RRT. Future research should focus on minimizing renal dysfunction in ECMO patients and define the optimal timing of RRT initiation.
Perfusion Strategy Using Axillary or Femoral Cannulation for Minimally Invasive Cardiac Surgery: Experience in 270 Patients with Computed Tomography-Based Criteria
We believe our CT-based perfusion strategy using AC or FC minimized brain embolic rates. AC can be a good alternative to prevent brain embolization for minimally invasive cardiac surgery patients with advanced atherosclerotic disease.
Use of the Hypotension Prediction Index During Cardiac Surgery
HPI predicted hypotensive episodes during cardiac surgeries with a high degree of sensitivity and specificity.
Prediction of Bleeding in Pediatric Cardiac Surgery Using Clinical Characteristics and Prospective Coagulation Test Results
Prospective coagulation testing marginally improves prediction of CCB during and after cardiac surgery but the clinical impact of this is small when compared to prediction using clinical characteristics.