Freeze-Dried Platelet-Rich Plasma Shows Beneficial Healing Properties in Chronic Wounds
Fresh platelet concentrates are used in many centers to treat recalcitrant wounds. To extend the therapeutic shelf-life of platelets, we analyzed the wound-healing effects of fresh-frozen and freeze-dried (FD) platelet-rich plasma (PRP) using a diabetic mouse model.
Automated Technique Accurately Measures Platelet Counts in “Platelet Gel” Products
A special blood concentrate known as platelet-rich plasma (PRP) can promote healing in a wide range of medical and surgical situations, but research has been limited by the lack of a universally accepted approach to measuring the platelet concentrations contained in PRP.
The Impact of Tissue Factor Pathway Inhibitor on Coagulation Kinetics Determined by Thrombelastography
Thrombelastography (TEG) is often used to monitor hemostasis in the perioperative period, and TFPI could potentially affect the diagnostic interpretation of TEG-based data, given its inhibition of both common and TF coagulation pathways. Thus, in this study we characterized the effect of TFPI on coagulation kinetics via TEG.
Aprotinin Improves Cerebral Protection: Evidence From a Survival Porcine Model
The goal of the study was to test the hypothesis that aprotinin could reduce cerebral injury after low-flow cardiopulmonary bypass and deep hypothermic circulatory arrest.
An Experience With Cardiopulmonary Bypass in HIV-Infected Patients
Having noted the good clinical status of some HIV patients who were referred for but refused surgery, we undertook surgery with the aim of determining outcome, risk-to-benefit ratio and, if possible, the effect of surgery with cardiopulmonary bypass (CPB) on the progression of their HIV disease.
Myocardial Protection in the Failing Heart: I. Effect of Cardioplegia and the Beating State Under Simulated Left Ventricular Restoration
Heart failure was induced by cardiac pacing to evaluate myocardial flow distribution of the open ventricle during delivery of either cardioplegia or in the beating state during simulated left ventricular restoration.
FDA Advisory Committee Strongly Endorses Use of Trasylol® in CABG Surgery Patients
Bayer was glad to participate in today’s advisory committee meeting held by the Cardiovascular and Renal Drugs Division of the U.S. Food and Drug Administration (FDA). This session provided an open forum in which to discuss the complex scientific issues surrounding the risk/benefit profile of Trasylol® (aprotinin injection) in detail.
Notice on Upcoming FDA Advisory Committee Meeting to Discuss Clinical Data for Aprotinin
Notice on Upcoming FDA Advisory Committee Meeting to Discuss Clinical Data for Aprotinin
Beating Heart Versus Conventional Cardiopulmonary Bypass: The Octopus Experience: A Randomized Comparison of 281 Patients Undergoing Coronary Artery Bypass Surgery With or Without Cardiopulmonary Bypass
The primary objective was to compare cognitive outcome between off-pump and on-pump coronary artery bypass surgery.
Off-Pump Coronary Artery Bypass Grafting. State of the Art 2006 and Results in Comparison with Conventional Coronary Artery Bypass Strategies
The decision between OPCAB and CCAB has to weigh several factors, including the likely risks and benefits of the two approaches for the particular patient, the experience of the surgeon, the complexity of the coronary disease, and the required coronary revascularization.
Cardiopulmonary Bypass and Renal Injury
Renal dysfunction following cardiopulmonary bypass (CPB) is well recognized. The extent of perioperative renal impairment ranges from subclinical injury to established renal failure requiring dialysis.
Failure of Surface-Modified Bypass Circuits to Improve Platelet Function During Pediatric Cardiac Surgery
Surface-modified cardiopulmonary bypass circuits have been shown to improve platelet function and decrease postoperative bleeding after heart surgery in adults.