Randomized, Double-Blinded, Placebo Controlled Study of Neuroprotection With Lidocaine in Cardiac Surgery
Cognitive decline after cardiac surgery remains common and diminishes patients' quality of life. Based on experimental and clinical evidence, this study assessed the potential of intravenously administered lidocaine to reduce postoperative cognitive dysfunction after cardiac surgery using cardiopulmonary bypass.
Acute Kidney Injury After Cardiac Surgery. Focus on Modifiable Risk Factors
The objective of the present study was to identify and determine the prognostic importance of such risk factors.
Effects of Mild Hypothermia and Rewarming on Renal Function After Coronary Artery Bypass Grafting
Hypothermia is a potential strategy for visceral organ protection during cardiopulmonary bypass (CPB). We report data from two randomized studies evaluating mild hypothermia and rewarming on postoperative renal function in cardiac surgical patients.
Long-term Extracorporeal Circulation Management: The Role of Low- and High-range Heparin ACT Tests
Modern management of extracorporeal circulation, especially during long-term support of post-cardiac surgical patients, remains challenging and requires optimal care of the patient’s fluid balance and coagulation hemostasis for its successful outcome.
Hypertonic Cardiopulmonary Bypass Primes and Endothelial Damage
The objective of this study was to investigate whether hypertonic hyperosmolar primes solution (HHPS), with an osmolarity of 2300 mOsmol/L, causes endothelial damage/loss.
Use of Multi-modality Life Support System
The purpose of this study was to describe the design and utilization of a multi-modality life support system (MMLSS), which is used to provide extracorporeal support for cases such as left heart bypass (LHB), extracorporeal life support (ECLS), veno-venous bypass, and hypothermic resuscitation.
Use of Recombinant Factor VIIa (NovoSeven) in Pediatric Cardiac Surgery
This study retrospectively evaluates rFVIIa administration for the treatment of severe bleeding in pediatric patients immediately after cardiac surgical procedures requiring CPB.
Hemolysis in Cardiac Surgery Patients Undergoing Cardiopulmonary Bypass: A Review in Search of a Treatment Algorithm
Hemolysis is a fact in all extracorporeal circuits, as shown in various studies by the increasing levels of plasma-free hemoglobin (PfHb) and decreasing levels of haptoglobin during and after cardiopulmonary bypass (CPB).
Vacuum-Assisted Venous Drainage and Gaseous Microemboli in Cardiopulmonary Bypass
When conventional gravity siphon venous drainage cannot achieve satisfactory venous drainage during minimally invasive cardiac and neonatal surgeries, assisted venous drainage techniques are needed to ensure adequate flow.
Aggressive Zero Balance Ultrafiltration on CPB in Patients with Renal Failure May Cause Cerebral Edema: A Theoretical Analysis
The objective of this study was to determine the brain volume changes that occur secondary to hemofiltration during cardiopulmonary bypass in patients with renal failure.
Effects of Modified Ultrafiltration on Coagulation as Measured by the Thromboelastograph
This study aimed to evaluate clot formation and strength, bleeding, and transfusions in adult subjects undergoing MUF. Nineteen subjects having primary coronary artery bypass, aortic, or mitral valve surgeries were recruited and randomized to having MUF (n = 10) or no-MUF (n = 9) performed after the termination of CPB.
Acid-Base Effects of a Bicarbonate-Balanced Priming Fluid During Cardiopulmonary Bypass: Comparison With Plasma-Lyte 148. A Randomised Single-Blinded Study
In an attempt to prevent this disturbance, we designed a bicarbonate-based crystalloid circuit prime balanced on physico-chemical principles with a strong ion difference of 24 mEq/l and compared its acid-base effects with those of Plasma-Lyte 148, a multiple electrolyte replacement solution containing acetate plus gluconate totalling 50 mEq/l.