Effect of Processing and Storage on Red Blood Cell Function In Vivo
Red blood cell (RBC) transfusion is indicated to improve oxygen delivery to tissue, and for no other purpose.
Selective Pulmonary Pulsatile Perfusion with Oxygenated Blood During Cardiopulmonary Bypass Attenuates Lung Tissue Inflammation but Does Not Affect Circulating Cytokine Levels
Improved respiratory outcome has been shown after selective pulsatile pulmonary perfusion (sPPP) during cardiopulmonary bypass (CPB).
Transfusion Thresholds and other Strategies for Guiding Allogeneic Red Blood Cell Transfusion
The purpose of this review is to compare clinical outcomes in patients randomised to restrictive versus liberal transfusion thresholds (triggers).
α-Tocopherol and Ascorbic Acid in Early Postoperative Period of Cardiopulmonary Bypass
To investigate whether α-tocopherol and ascorbic acid have effect on the suppression of inflammation in the early postoperative period after open heart surgery.
Changes in Microvascular Reactivity after Cardiopulmonary Bypass in Patients with Poorly Controlled versus Controlled Diabetes
Poorly controlled diabetes results in impaired arteriolar function before and after CPB.
Cell-Derived Microparticles in Stored Blood Products: Innocent-Bystanders or Effective Mediators of Post-Transfusion Reactions?
Plasma membrane-derived microvesicles or microparticles (MPs) are sub-cellular vesicles released upon shear stress, cell activation, injury or apoptosis.
Peroperative Effects of Fresh Frozen Plasma and Antithrombin III on Heparin Sensitivity and Coagulation during Nitroglycerine Infusion in Coronary Artery Bypass Surgery
ATIII may be preferred to FFP in patients with heparin resistance due to NTG infusion undergoing CABGS.
The Age of Blood Evaluation (ABLE) Randomized Controlled Trial: Study Design
The "Age of Blood Evaluation" (ABLE) study (ISRCTN44878718) is a double-blind, multicenter, parallel randomized controlled clinical trial.
Impact of Transfusion of Autologous 7- versus 42-Day-Old AS-3 Red Blood Cells on Tissue Oxygenation and the Microcirculation in Healthy Volunteers
Transfusion of 1 unit of 42-day-stored RBCs to healthy subjects has no overt detrimental effect on tissue oxygenation or the microcirculation assessed by clinically available monitors.
A Pilot Feasibility Trial of Allocation of Freshest Available Red Blood Cells versus Standard Care in Critically Ill Patients
We aimed to evaluate in intensive care unit (ICU) patients 1) the feasibility of allocating freshest available compatible RBCs versus standard care and 2) the suitability of this approach in the design of a large randomized controlled trial (RCT).
Prospective Validation of the Vasoactive-Inotropic Score and Correlation to Short-Term Outcomes in Neonates and Infants after Cardiothoracic Surgery
In neonates and infants, a higher VIS at 48 h after cardiothoracic surgery is strongly associated with increased length of ventilation, and prolonged ICU and total hospital stay.
Near-Infrared Spectroscopy Cerebral and Somatic (Renal) Oxygen Saturation Correlation to Continuous Venous Oxygen Saturation via Intravenous Oximetry Catheter
In this small cohort of pediatric patients undergoing heart surgery, there was a moderate but statistically significant correlation between the ScvO(2)-catheter and the NIRS-C values.