Incidence of Thrombotic Complications in Critically Ill ICU Patients with COVID-19
Our findings reinforce the recommendation to strictly apply pharmacological thrombosis prophylaxis in all COVID-19 patients admitted to the ICU, and are strongly suggestive of increasing the prophylaxis towards high-prophylactic doses, even in the absence of randomized evidence.
Regional Planning for Extracorporeal Membrane Oxygenation Allocation During COVID-19
Drawing from a collaborative framework developed by one United States metropolitan area with multiple adult and pediatric extracorporeal life support centers, this article aims to inform decision-making around ECMO use during a pandemic such as COVID-19.
Protecting High-Risk Cardiac Patients During the COVID-19 Outbreak
During the ongoing health emergency, all new patients admitted to hospital units hosting immunocompromised; complex; critical; and, more generally, acutely ill patients probably should be isolated initially and screened for SARS-CoV-2 infection, and separate pathways should be provided until the virological test results are obtained.
Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19)
The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new recommendations in further releases of these guidelines.
Testing an Old Therapy Against a New Disease: Convalescent Plasma for COVID-19
For now—and possibly the next 18 to 24 months, convalescent plasma, despite supply issues and questions about efficacy and who is most likely to benefit from treatment, remains the only off-the-shelf therapy for COVID-19.
A Narrative Review of Antithrombin Use During Veno-Venous Extracorporeal Membrane Oxygenation in Adults: Rationale, Current Use, Effects on Anticoagulation, and Outcomes
Antithrombin use in veno-venous extracorporeal membrane oxygenation should be investigated on the threshold for supplementation, dose, and time of administration.
Antifibrinolytics and Cardiac Surgery: The Past, the Present, and the Future
Pharmacological as well as nonpharmacological strategies have been used to reduce blood loss. Among the pharmacological approaches, antifibrinolytic drugs are the mainstay.
Coagulation Test Changes Associated with Acute Normovolemic Hemodilution in Cardiac Surgery
In patients undergoing cardiac surgery requiring CPB, ANH results in significant improvements of aPTT, fibrinogen and hemoglobin values; however, the true clinical significance is questionable. In the absence of ongoing surgical bleeding, there appears to be normalization of coagulation tests (excluding fibrinogen) following CPB.
Del Nido Cardioplegia in Coronary Surgery: a Propensity-Matched Analysis
In this large cohort of CABG patients, DNC was shown as a safe alternative to CC and was associated with lower postoperative dysrhythmia and infection rates.
Hyperoxemia and Excess Oxygen Use in Early Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study
Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort.
Biomarker-Guided Implementation of the KDIGO Guidelines to Reduce the Occurrence of Acute Kidney Injury in Patients after Cardiac Surgery (PrevAKI-multicentre): Protocol for a Multicentre, Observational Study Followed by Randomised Controlled Feasibility Trial
The purpose of the observational survey is to explore the adherence to the KDIGO recommendations in routine clinical practice. The second phase is a randomised controlled trial. The objective is to investigate whether the trial protocol is implementable in a large multicentre, multinational setting.
Preconditioning Strategies to Prevent Acute Kidney Injury
In this review, the most attractive strategies and the current mechanistic concepts are introduced and discussed. Furthermore, we present clinical trials evaluating the feasibility of preconditioning in the clinical setting.