Cardiopulmonary Bypass-Induced Coagulopathy in Paediatric Patients: The Role of Platelets in Postoperative Bleeding. A Preliminary Study
Postoperative bleeding in children undergoing cardiac surgery with CPB was linked to younger age, longer CPB duration and significant postoperative reduction in platelet count and function. Larger studies are needed to confirm our results and define strategies to reduce postoperative bleeding in these patients.
Dose Estimation for Bivalirudin during Pediatric Cardiopulmonary Bypass
Bivalirudin infusion in children should be started after loading dose at rates greater than those used in adults. Dose in neonates remains uncertain because neither pharmacokinetics nor coagulation pharmacodynamics have been adequately characterized.
Hyperoxia During Cardiopulmonary Bypass Is Associated With Mortality in Infants Undergoing Cardiac Surgery
Hyperoxia during cardiopulmonary bypass was an independent risk factor for mortality and may be a modifiable risk factor. Furthermore, hyperoxia during cardiopulmonary bypass was associated with four-fold greater odds of mortality within 30 days of surgery.
Prediction of Bleeding in Pediatric Cardiac Surgery Using Clinical Characteristics and Prospective Coagulation Test Results
Prospective coagulation testing marginally improves prediction of CCB during and after cardiac surgery but the clinical impact of this is small when compared to prediction using clinical characteristics.
Management of Congenital Cardiac Surgery During COVID-19 Pandemic
In this article, we present crucial precautions that were applied in paediatric cardiovascular surgery and extensive list of cases in order to deliver highest level of the patient safety and protection for the surgical team.
The Great Ormond Street Hospital Immunoadsorption Method for ABO-Incompatible Heart Transplantation: a Practical Technique
We have subsequently used this technique in all children undergoing ABO-incompatible heart transplantation and become convinced of its efficacy in this population while observing no adverse effects. This article outlines the practical details required to perform the technique in order to avoid hyperacute rejection.
In Vitro Evaluation of Flow Distribution in All-Region Perfusion during the Norwood Operation
For all-region perfusion during the Norwood operation, primary CPB arterial flow should be divided to the head and coronary circulation with an independent pump delivering flow to the descending aorta. This should avoid cerebral over-circulation and insufficient flow to the lower body.
Sustained Total All-Region (STAR) Perfusion: An Optimized Perfusion Strategy for Norwood Reconstruction
STAR perfusion allows the Norwood procedure to be completed with mild hypothermia and continuous perfusion to all vascular beds with reduced cardiopulmonary bypass as well as total operative times. This technique is successfully achieved with minimal changes to circuitry, minor modifications to heart-lung machine servoregulation and few additional cannulation disposables.
Investigation of Myocardial Protection During Pediatric CPB: Practical Experience in 100 Chinese Hospitals
In conclusion, the essence of myocardial protection management during pediatric CPB was cardiac arrest induced by cardioplegia under systemic hypothermia. However, there is no uniform standard for the type of cardioplegia, or dosages. Therefore, well-designed multicenter randomized controlled trials are warranted to provide tangible evidence for myocardial protection of cardioplegia in pediatric CPB.
Pediatric Intensive Care Preparedness and ECMO Availability in Children With COVID-19: An International Survey
In conclusion, both the experience in managing patients and the availability of neonatal/pediatric ECMO in the centers the responders are working seemed to increase physicians’ preparedness.
Efficacy and Safety of Corticosteroids Prophylaxis in Cardiac Surgery: A Protocol for Systematic Review and Meta-Analysis
This study will compare the efficacy of prophylactic corticosteroids for adults and children undergoing cardiac surgery with CPB. Due to the nature of the disease and intervention methods, randomized controlled trials may be inadequate, and we will carefully consider inclusion in high-quality, non-randomized controlled trials, but this may result in high heterogeneity and affect the reliability of the results.
Impact of Corticosteroids on Cardiopulmonary Bypass Induced Inflammation in Children:A Meta-Analysis
CS were found to have a favorable impact on postoperative fluid balance and may be associated with shortening the duration of mechanical ventilation. While CS had no impact on mortality, they may be beneficial, particularly in neonates and those undergoing high complexity surgery.