Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass
Dexmedetomidine is increasingly used off-label in infants and children with cardiac disease during cardiopulmonary bypass (CPB) and in the postoperative period.
Part II. Comparison of Neurodevelopmental Outcomes Between Normothermic and Hypothermic Pediatric Cardiopulmonary Bypass
Our study did not reveal any significant differences in early neurodevelopmental outcomes between H-CPB or N-CPB surgery for congenital heart defects.
Platelet Function Changes during Neonatal Cardiopulmonary Bypass Surgery: Mechanistic Basis and Lack of Correlation with Excessive Bleeding
Thrombocytopenia and platelet dysfunction induced by extracorporeal blood circulation are thought to contribute to postsurgical bleeding complications in neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB).
Recovery of Cefazolin and Clindamycin in In Vitro Pediatric CPB Systems
Recovery of cefazolin was high in the neonatal and infant CPB systems and moderate in the pediatric system. We found a large discrepancy between the theoretical and measured concentrations of clindamycin in all tested CPB systems.
Cardiopulmonary Bypass Strategy to Facilitate Transfusion-Free Congenital Heart Surgery in Neonates and Infants
Bloodless CPB circuit priming should become a widespread reality, even in neonates and young infants, in any open-heart procedure.
Kidney Disease: Improving Global Outcomes in Neonates with Acute Kidney Injury After Cardiac Surgery
Acute kidney injury (AKI) after cardiac surgery (CS-AKI) in children with congenital heart disease is a serious complication closely associated with high morbidity and mortality.
Toddler Neurodevelopmental Outcomes Are Associated With School-Age IQ in Children With Single Ventricle Physiology
To examine whether neurodevelopment at preschool age predicts IQ levels and needs for special education services in school-age children with single ventricle (SV) physiology.
Ultrafiltration in Pediatric Cardiac Surgery Review
Ultrafiltration has some essential benefit as it is ubiquitously used at pediatric heart centers; however, the optimal protocol could be yet identified.
Serum Levels of Interleukin-6, Interleukin-8, Interleukin-10, and Tumor Necrosis Factor-α, Renal Function Biochemical Parameters and Clinical Outcomes in Pediatric Cardiopulmonary Bypass Surgery
Higher circulatory pro-inflammatory cytokine level is associated with adverse outcomes such as increased intensive care unit stay and longer mechanical ventilation time in pediatric patients.
Fresh Frozen Plasma versus Crystalloid Priming of Cardiopulmonary Bypass Circuit in Pediatric Surgery: A Randomized Clinical Trial
The results demonstrate that in infants and children, priming CPB with crystalloids does not result in a different risk of postoperative bleeding and need for transfusion of allogeneic blood products.
Developments in Pediatric Ventricular Assist Device Support
Mechanical support devices have revolutionized the management of circulatory failure.
Effect of Blood Flow on Platelets, Leukocytes, and Extracellular Vesicles in Thrombosis of Simulated Neonatal Extracorporeal Circulation
Extracorporeal membrane oxygenation (ECMO) has frequent and sometimes lethal thrombotic complications.