Fibrinogen Supplementation in Cardiac Surgery: Where Are We Now And Where Are We Going?
Studies have emphasized the importance of normal fibrinogen concentrations in surgical patients.
Numerical Investigation of a Novel Aortic Cannula Aimed at Reducing Cerebral Embolism during Cardiovascular Bypass Surgery
The aim of the current work was to numerically investigate the hemodynamic efficiency and feasibility of a novel, backward suction cannula (BSC), designed to drastically reduce the potential risk for cerebral emboli (CEP).
PHD2 Silencing Enhances the Survival and Paracrine Function of Transplanted Adipose-Derived Stem Cells in Infarcted Myocardium
We studied if and how Prolyl hydroxylase domain protein 2 silencing in human adipose-derived stem cells (ADSCs) enhances their cardioprotective effects after transplantation into infarcted hearts.
Low Hemorrhage-Related Mortality in Trauma Patients in a Level I Trauma Center Employing Transfusion Packages and Early Thromboelastography-Directed Hemostatic Resuscitation with Plasma and Platelets
This was a prospective study of adult trauma patients admitted to a Level I trauma center. Demography, Injury Severity Score (ISS), transfusion therapy, and mortality were registered. Hemostatic resuscitation was based on a massive transfusion protocol encompassing transfusion packages and thromboelastography (TEG)-guided therapy.
Combination Therapy of Human Adipose-Derived Stem Cells and Basic Fibroblast Growth Factor Hydrogel in Muscle Regeneration
In this study, we determined whether the combination therapy using human adipose-derived stem cells (h-ADSCs) and basic fibroblast growth factor (bFGF) incorporated into hydrogel could enhance muscle regeneration in a muscle laceration animal model.
TEG-guided Resuscitation is Superior to Standardized MTP Resuscitation in Massively Transfused Penetrating Trauma Patients
In this study we hypothesized that TEG-directed resuscitation is equivalent to massive transfusion protocol resuscitation.
Influence of Tranexamic Acid on Postoperative Autologous Blood Retransfusion in Primary Total Hip and Knee Arthroplasty: A Randomized Controlled Trial
In this study, we hypothesized that adding tranexamic acid (TXA) to a restrictive blood transfusion protocol would reduce the need for postoperative autologous blood retransfusion in primary knee and hip arthroplasty.
Use of a Massive Transfusion Protocol in Nontrauma Patients: Activate Away
The current study was designed to investigate whether a massive transfusion protocol could be used effectively in general medical/surgical patients without detrimentally impacting resource allocation.
The Relationship Between Fibrinogen Levels After Cardiopulmonary Bypass and Large Volume Red Cell Transfusion in Cardiac Surgery: An Observational Study
The relationship between post-CPB fibrinogen levels and large volume red cell transfusion was explored in this study.
Processed Residual Pump Blood in Cardiac Surgery: The Processed Residual Blood in Cardiac Surgery Trial
This study seeks to establish if processing residual CPB volume with ultrafiltration reduces homologous blood transfusion and bleeding.
Open Aortic Valve Replacement in a Patient with Glanzmann’s Thrombasthenia: A Multidisciplinary Strategy to Minimize Perioperative Bleeding
Patients with GT requiring cardiac surgical procedures are at high risk for perioperative bleeding complications. This case report illustrates the importance of multidisciplinary planning, TEG analysis, and the judicious use of recombinant factors to minimize operative bleeding risk.
Earlier Detection of Coagulopathy with Thromboelastometry During Pediatric Cardiac Surgery: A Prospective Observational Study
This study helps to determine whether thromboelastometry (TEM) analysis before weaning from cardiopulmonary bypass (CPB) and hemoconcentration is predictive of post-CPB results and whether analysis of clot firmness already after 10 min yields reliable results.