Cardiovascular Tissue Engineering Research Support at the National Heart, Lung, and Blood Institute
This article is a review of the tissue engineering programs of the National Heart, Lung, and Blood Institute, which support research efforts to translate novel approaches for the treatment of cardiovascular disease.
Fabrication of Small-Diameter Vascular Scaffolds by Heparin-Bonded P(LLA-CL) Composite Nanofibers to Improve Graft Patency
The poor patency rate following small-diameter vascular grafting remains a major hurdle for the widespread clinical application of artificial bloodvessels to date.
Blood Substitutes: Evolution from Non Carrying to Oxygen-and Gas-Carrying Fluids
The development of oxygen (O2)-carrying blood substitutes has evolved from the goal of replicating blood O2 transport properties to that of preserving microvascular and organ function, reducing the inherent or potential toxicity of the material used to carry O2, and treating pathologies initiated by anemia and hypoxia.
Orthotopic Replacement of Aortic Heart Valves with Tissue-Engineered Grafts
This study presents the function and morphological changes of a tissue-engineered aortic valve (TEV) compared to the cryopreserved valve (CPV), aortic valve (AV) allografts in an orthotopic position in sheep.
The Approach to Patients with Bleeding Disorders Who Do Not Accept Blood-Derived Products
Despite the widespread use of allogeneic blood components in clinical practice, there are patients in whom transfusion cannot be carried out for various reasons, including refusal of transfusions because of religious beliefs.
Should Jehovah’s Witness Patients be Listed for Heart Transplantation
This best evidence topic in Cardiac Surgery was written according to a structured protocol. The question addressed was: for [Jehovah's Witness patients with end-stage heart failure] can these patients undergo a [heart transplantation] without an increased rate of mortality.
Patient Blood Management – The New Frontier
As one of the oldest and most common procedures in clinical practice, allogeneic blood transfusions face many issues including questionable safety and efficacy, increasing costs and limited supply.
A Retrospective Comparison of Blood Transfusion Requirements During Cardiopulmonary Bypass with Two Different Small Adult Oxygenators
A low haematocrit during cardiopulmonary bypass (CPB) is associated with adverse outcomes and often results in homologous blood transfusions.
A Novel Method for the Direct Determination of Heparin Concentration During Cardiopulmonary Bypass Surgery
The aim of this prospective study was to test a novel light scattering assay (LiSA) for the direct determination of heparin concentration during cardiopulmonary bypass (CPB) surgery and to compare the heparin concentrations with routinely determined activated clotting time (ACT).
Cerebral Oximetry and Cardiac Arrest
This systematic review, which is based on a Medline search, focuses on the characteristic changes in regional cerebral oxygen saturation that occur, when global oxygen supply to the brain ceases.
Comparison of the Effects of Desflurane and Propofol Anesthesia on the Inflammatory Response and S100β Protein During Coronary Artery Bypass Grafting
The aim of this study was to assess the effect of propofol versus desflurane anesthesia on systemic immune modulation and central nervous system on patients undergoing coronary artery bypass grafting.
Home Telemonitoring Study for Japanese Patients with Heart Failure (HOMES-HF): Protocol for a Multicentre Randomised Controlled Trial
The aim of the present study was to investigate whether an HF management programme using telemonitoring could improve outcomes in patients with HF under the Japanese healthcare system.