Direct Evidence of Endothelial Injury During Cardiopulmonary Bypass by Demonstration of Circulating Endothelial Cells
Circulating endothelial cells have recently been established as a novel marker of endothelial damage in a variety of vascular disorders.
Influence of Hematocrit and Pump Prime on Cerebral Oxygen Saturation in On-Pump Coronary Revascularization
The couplings between cerebral oxygenation (rSO2), on-pump hematocrit and circuit prime are explored in this study.
Is Body Surface Area Still the Best ay to Determine Pump Flow Rate During Cardiopulmonary Bypass?
The aim of this study was to determine which factors, including body surface area, body mass index and lean body mass, best predict SvO2 during CPB.
Cardiopulmonary Bypass in the Immature Fetus Through Novel Use of a Mini-Centrifugal Pump
The concept that the natural history of certain heart defects could be positively modified through in utero intervention has stimulated extensive research in fetal cardiac intervention and surgery since the early 1980s.
Changes in Muscle Compartment Pressure After Cardiopulmonary Bypass
Purpose: Hemodilution and inflammation lead to edema and increased muscle compartment pressure after cardiac surgery. The aim of this study was to find whether muscle compartment pressure was affected by the addition of albumin and mannitol to the pump prime, heparin coating or leukocyte depletion. Additionally, we studied the relationship between intraocular pressure and lower leg muscle compartment pressure. Edema during and following cardiac surgery is due to hemodynamic, osmotic and inflammatory changes, according to Starling's Law. We attempted to influence the osmotic balance and reduce the inflammatory response in order to reduce the edema. Methods: Thirty-six patients who underwent cardiac surgery were randomly allocated into four groups. Group A received albumin and mannitol into the pump prime. Group B had an, heparin-coated perfusion system, Group C had a leukocyte-depletion arterial line filter and Group D was the control group, where intraocular pressure was also measured. Results: Lower leg muscle compartment pressure increased significantly during and after cardiac surgery in all groups, but this increase was significantly less in Group A than in the control group 24 h after surgery. No correlation was found between muscular compartment pressure and intraocular pressure. The intraocular pressure profile is different from the muscular compartment pressure and recovers much faster. Conclusion: Lower leg muscle compartment pressure and intraocular pressure behave differently during and after cardiac surgery. Albumin and mannitol added to the pump prime decreases muscle compartment pressure after cardiac surgery.
Coronary Artery Bypass is Superior to Drug-Eluting Stents in Multivessel Coronary Artery Disease
Ethical considerations demand that patients with multivessel disease be informed of the documented mortality benefit of coronary bypass graft surgery.
Long-Term Outcomes of Coronary-Artery Bypass Grafting Versus Stent Implantation
Several studies have compared outcomes for coronary-artery bypass grafting (CABG) and percutaneous coronary intervention (PCI), but most were done before the availability of stenting, which has revolutionized the latter approach.
Randomized Controlled Trial of Pericardial Blood Processing With a Cell-Saving Device on Neurologic Markers in Elderly Patients Undergoing Coronary Artery Bypass Graft Surgery
The present study tested the hypothesis that processing of pericardial shed blood with a cell-saving device during cardiopulmonary bypass would significantly decrease serum levels of protein S100B, and improve brain oxygen saturation and neurologic outcome, all markers of brain injury in elderly patients.
Intraaortic Balloon Pumping During Cardioplegic Arrest Preserves Lung Function in Patients With Chronic Obstructive Pulmonary Disease
We evaluated differences in lung function of patients with COPD undergoing preoperative intraaortic balloon pumping (IABP), between linear flow during cardiopulmonary bypass (IABP-off) and maintenance of pulsatile flow (IABP-on at automatic 80 bpm) during cardioplegic arrest.
Intermittent Pressure Augmentation During Retrograde Cerebral Perfusion Under Moderate Hypothermia Provides Adequate Neuroprotection: An Experimental Study
For cerebral protection during aortic surgery, we introduced a novel retrograde cerebral perfusion method with intermittent pressure augmentation.
Evaluation of Myocardial Metabolism With Microdialysis After Protection With Cold Blood or Cold Crystalloid Cardioplegia. A Porcine Model
In an acute porcine model we examined two standard cardioplegic methods. Myocardial microdialysis was used to investigate the metabolism during cardioplegic arrest and in the reperfusion period.
The Hemodynamic Effects of Methylene Blue When Administered at the Onset of Cardiopulmonary Bypass
In this study we examined the hemodynamic effects of methylene blue (MB), an inhibitor of guanylate cyclase, administered during cardiopulmonary bypass (CPB) to patients taking angiotensin-converting enzyme inhibitors.