The Early Inflammatory Response in A Mini-Cardiopulmonary Bypass System: A Prospective Randomized Study
The Medtronic RHS may induce less systemic inflammation than conventional CPB systems, particularly when cardiotomy suction was used, but it did not result in improved clinical benefit.
The Volatile Anesthetic Sevoflurane Inhibits Activation of Neutrophil Granulocytes During Simulated Extracorporeal Circulation
Sevoflurane inhibits granulocyte activation during ex vivo ECC and therefore has the potential to decrease the ECC-triggered inflammatory response.
Safety of Training and Assessment in Operating Theatres – A Systematic Review and Meta-Analysis
This article establishes a systematic evidence base for the safety of training in the operating theatre.
Vasoreactivity Changes During Extracorporeal Circulation: Effects of Halogenated Agents
Absence of deleterious effects in SVR decrease when administering isoflurane during normothermic CPB was assumed but prospective comparative studies comparing effects of halogenated agents and other anesthetic agents are needed in order to confirm these findings.
Right Ventricular Failure after Cardiac Surgery
Techniques for managing the pulmonary circulation and strategies for optimizing RV function in various clinical settings are presented.
The Effects of Sevoflurane Anesthesia and Cardiopulmonary Bypass on Renal Function in Cyanotic and Acyanotic Children Undergoing Cardiac Surgery
We have concluded that renal function was not affected during open heart surgery with sevoflurane anesthesia, in both cyanotic and acyanotic children.
A Review of Postoperative Cognitive Dysfunction and Neuroinflammation Associated with Cardiac Surgery and Anaesthesia
We briefly discuss the evidence for cardiopulmonary bypass-related neuronal injuries in adult cardiac surgery patients, and review the evidence that immune priming is a key factor in the pathogenesis of cognitive dysfunction after cardiac surgery.
Percutaneous Mechanical Support for the Failing Right Heart
This article considers the available mechanical approaches to provide hemodynamic support to treat profound RV failure in the common clinical scenarios in which percutaneous mechanical RV support may be most beneficial.
Short-Acting P2Y12 Blockade to Reduce Platelet Dysfunction and Coagulopathy During Experimental Extracorporeal Circulation and Hypothermia
This experimental study tested P(2)Y(12) receptor blockade as an approach to protect platelets during ECC.
Non-Invasive Estimation of Jugular Venous Oxygen Saturation: A Comparison Between Near Infrared Spectroscopy and Transcutaneous Venous Oximetry
Placement of cerebral oximetry patches directly over the internal jugular vein (as opposed to on the forehead) appeared to approximate internal jugular venous saturation better...
Plutonium-238: An Ideal Power Source for Intracorporeal Ventricular Assist Devices?
Ventricular assist devices emerged as a widely used modality for treatment of end-stage heart failure; however, despite significant advances, external energy supply remains a problem contributing to significant patient morbidity and potential mortality.
Population Pharmacokinetics of Olprinone in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass
Therefore, the purpose of this study was to determine olprinone pharmacokinetic parameters in a large population undergoing cardiac surgery with CPB.