Predicting Survival After Extracorporeal Membrane Oxygenation by Using Machine Learning
This proof of concept study demonstrates the potential for machine learning models to augment clinical decision making for patients undergoing VA-ECMO. Further development with multi-institutional data is warranted.
Feasibility of Venovenous Extracorporeal Membrane Oxygenation Without Systemic Anticoagulation
Our results suggest that venovenous ECMO can be safely administered without continuous systemic anticoagulation therapy. This approach may be associated with reduced bleeding diathesis and need for blood transfusions.
Physiology of Extracorporeal Gas Exchange
Artificial lungs are mechanical devices in which blood is exposed to oxygen through a gas permeable membrane. Like the normal lung, the amount of gas exchange is controlled by the geometry of the device, the blood flow and composition, and the ventilating gas flow and composition.
COVID-19 Associated Hypercoagulability Manifestations, Mechanisms, and Management
In this narrative review, we summarize clinical manifestations of COVID-19, mechanisms, monitoring considerations, and anticoagulant therapy. We also review unique considerations for COVID-19 patients who are on extracorporeal membrane oxygenation.
Anti-Xa Versus Time-Guided Anticoagulation Strategies in Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis
In this meta-analysis of observational studies of patients on ECMO, an anti-Xa-based anticoagulation strategy, when compared to a time-based strategy, was associated with fewer bleeding events and mortality rate, without an increase in thrombotic events.
External Validation of The Pediatric Extracorporeal Membrane Oxygenation Prediction Model for Risk Adjusting Mortality
While the model overestimates mortality for the highest risk patients, it remains the only prediction model applicable to both neonates and pediatric patients who require ECLS for any indication and thus maintains potential for application in research and quality benchmarking.
Mobile Extracorporeal Membrane Oxygenation: 5-Year Experience of a French Pediatric and Neonatal Center
We describe one of the largest cohorts of infants and children transported by a mobile unit while on extracorporeal membrane oxygenation. Our findings confirm that it is safe to start extracorporeal membrane oxygenation in a referring center and to transport patients using an extracorporeal membrane oxygenation mobile team.
Risk Factors for Complete Recovery of Adults After Weaning from Veno-Venous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Failure: An Analysis from Adult Patients in The Extracorporeal Life Support Organization Registry
Complete recovery after veno-venous ECMO support is associated with the patient’s baseline condition, ECMO duration, and ECMO-related complications. Respiratory ECMO should aim to increase both the survival and the quality of life after weaning from ECMO.
Hemodynamic Monitoring in Patients With Venoarterial Extracorporeal Membrane Oxygenation
This article provides an overview of VA-ECMO pathophysiology, and reviews current knowledge of hemodynamic monitoring assessments in patients with peripheral VA-ECMO.
Right Watershed Cerebral Infarction Following Neck Cannulation for Veno-Arterial Extracorporeal Membrane Oxygenation in Pediatric Septic Shock: A Case Series
The risk of ipsilateral watershed injury should be considered before cervical cannulation, notably in the context of sepsis.
Role of Extracorporeal Membrane Oxygenation In COVID-19: A Systematic Review
Our study highlights the paucity of evidence and the need for further data to consolidate the efficacy of ECMO in improving patient outcomes.
Provision of ECPR during COVID-19: Evidence, Equity, and Ethical Dilemmas
The logistics of patient selection, expedient cannulation, healthcare worker safety, and post-resuscitation care must be weighed against the ethical considerations.