Rationale for the Role of Heparin and Related GAG Antithrombotics in COVID-19 Infection
The SARS-CoV-2 pandemic has focused attention on prevention, restriction and treatment methods that are acceptable worldwide. This means that they should be simple and inexpensive. This review examines the possible role of glycosaminoglycan (GAG) antithrombotics in the treatment of COVID-19. The pathophysiology of this disease reveals a complex interplay between the hemostatic and immune systems that can be readily disrupted by SARS-CoV-2.
Cardiac Surgery Outcomes in an Epicenter of the COVID-19 Pandemic
The outcomes demonstrated herein suggest that with proper infection control, isolation, and patient selection, results similar to those observed in non-COVID series can be replicated.
Veno-Venous Extracorporeal Membrane Oxygenation Allocation in the COVID-19 Pandemic
In discussing how to best manage these issues in the COVID-19 pandemic at present, we identify gaps in the literature and policy important to clinicians as this crisis continues.
SARS-CoV-2 Does Not Spread Through Extracorporeal Membrane Oxygenation or Dialysis Membranes
Though our findings may not alter practices, they may contribute to address legitimate interrogations raised by caregivers and reinforce adhesion and trust into infection control measure policies, which is likely to play a major role against the outbreak spreading.
Polypropylene Oxygenators: Risk Of SARS-Cov-2 Contamination in The Operation Theatre?
In summary, although there is no evidence-based research to support that membrane oxygenators used during CPB could be another source of SARS-CoV-2 transmission, simple precautions like the vacuum suction or filtration should be recommended, until we assure it is not necessary.
Management of Congenital Cardiac Surgery During COVID-19 Pandemic
In this article, we present crucial precautions that were applied in paediatric cardiovascular surgery and extensive list of cases in order to deliver highest level of the patient safety and protection for the surgical team.
Evidence-Based Practical Guidance for the Antithrombotic Management in Patients With Coronavirus Disease (COVID-19) in 2020
The objective is to keep this guidance very practical, highlighting the knowledge gaps and areas of uncertainty where randomized clinical trials (RCTs) are desperately needed.
Pediatric Intensive Care Preparedness and ECMO Availability in Children With COVID-19: An International Survey
In conclusion, both the experience in managing patients and the availability of neonatal/pediatric ECMO in the centers the responders are working seemed to increase physicians’ preparedness.
Successful Use of An Automated Proning System to Achieve Prone Positioning in A Patient with Severe ARDS Requiring Veno-Venous ECMO
To our knowledge, this is the first description in the literature of using an automated proning system with an ECMO circuit in place. This report describes the technique we used to safely perform axial rotations for two days with fewer providers required than manual proning.
Anticoagulation Management in Severe Coronavirus Disease 2019 Patients on Extracorporeal Membrane Oxygenation
Hypercoagulability and secondary hyperfibrinolysis during ECMO support in COVID-19 patients are common and possibly increase the propensity for thrombotic events and failure of the oxygenator. Currently, there is not enough evidence to support a more aggressive anticoagulation strategy.
Use of Dialysis, Tracheostomy, and Extracorporeal Membrane Oxygenation Among 240,392 Patients Hospitalized With COVID-19 in the United States
Although less than one percent of patients undergo tracheostomy and ECMO, the absolute numbers of patients who have undergone these interventions is substantial and can be expected to continue grow given the continuing spread of the COVID-19.
Extracorporeal Membrane Oxygenation (ECMO) in Patients with COVID-19: A Rapid Systematic Review of Case Studies
ECMO plays an important role in the stabilization and survival critically ill patients with COVID-19, but the usefulness of ECMO in reducing the mortality of severe ARDS caused by COVID-19 was limited.