Fibrinolysisv.1.0
Fibrinolysis Fibrinolysis is the dissolution of the clot formation process involving the plasma protein plasminogen. This system of enzymes dissolves blood clots […]
The Extracorporeal Circuit v.1
The Extracorporeal Circuit Diversion of blood from the operative site, via an extracorporeal circuit (ECC) is necessary to proceed with open heart […]
Protamine
Protamine Protamine, a polycationic protein derived from salmon milt, possess strong alkalinity because of an amino acid composition consisting of 67% arginine. […]
Coagulopathies
Coagulopathies The most common cause of intraoperative coagulopathy is thrombocytopenia secondary to hemodilution. Thrombocytopenia is a condition where the circulating platelet count […]
Common Pathway (Coagulation)
The endpoint of activity for both the extrinsic and intrinsic pathways for coagulation is the activation of factor X. Reactions beyond this […]
Jehovah’s Witness v.1
JEHOVAH’S WITNESSES Jehovah’s Witness patients are at increased risk for morbidity and mortality associated with blood loss due to their refusal, on […]
Malignant Hyperthermia v 1
I. PATHOPHYSIOLOGY: Malignant hyperthermia (MH) is a pharmacogenetic disorder characterized by a fulminant hypermetabolic reaction of skeletal muscle induced by volatile inhalational […]
Coagulation Cascade (V.1)
Intrinsic Pathway The coagulation cascade is initiated when blood becomes traumatized by exposure to a foreign surface. An example of this […]