The Predictive Value of Multiple Electrode Platelet Aggregometry (Multiplate) in Adult Cardiac Surgery
The purpose of this retrospective observational study is to analyze the value of multiple electrode platelet aggregometry (Multiplate analyzer, Verum Diagnostica, Munich) as a point-of-care (POC) device in adult cardiac surgical patients.
Fibrinogen Concentrate Reduces Intraoperative Bleeding when used as First-Line Hemostatic Therapy During Major Aortic Replacement Surgery: Results from a Randomized, Placebo-Controlled Trial
We assessed whether fibrinogen concentrate as targeted first-line hemostatic therapy was more effective than placebo or a standardized transfusion algorithm in controlling coagulopathic bleeding in patients undergoing major aortic surgery.
The Relationship Between Intraoperative Blood Transfusion and Postoperative Systemic Inflammatory Response Syndrome
Previous observations suggest that intraoperative blood transfusion (IBT) is a risk factor for adverse postoperative outcomes. IBT alters immune function and may predispose to systemic inflammatory response syndrome (SIRS).
Perfusion Tubing: Standardized or Modify?
I applaud our adult colleagues in trying to do what is best for the patient even if standardized tubing packs have to be modified resulting in higher prices as some would argue.
Meta-Analysis of the Studies of Bleeding Complications of Platelets Pathogen-Reduced with the Intercept System
Treatment with Intercept may increase the risk of all and clinically significant (albeit not severe) bleeding complications in RCTs maintaining a platelet count of ≥10×10(9) or ≥20×10(9)/l through increased platelet transfusions.
Transfusion of Older Stored Blood and Risk of Death: A Meta-Analysis
Based on available data, use of older stored blood is associated with a significantly increased risk of death.
How we Provide Transfusion Support for Neonatal and Pediatric Patients on Extracorporeal Membrane Oxygenation
In this article, we describe our protocol for transfusion support for ECMO and potential ECMO patients.
Impact of Red Blood Cell Transfusion on Global and Regional Measures of Oxygenation
This article will review fundamental aspects of oxygen delivery and extraction, and the effects of red blood cell transfusion on tissue oxygenation as well as the microcirculation.
Influence of Hemodynamic Variations on the Pharmacokinetics of Landiolol in Patients Undergoing Cardiovascular Surgery
We investigated the influence of hemodynamic variation and the following hepatocirculatory changes after systemic heparinization on the pharmacokinetics of landiolol in patients undergoing cardiovascular surgery under cardiopulmonary bypass.
Formation of Intracardiac Thrombus During Cardiopulmonary Bypass Despite Full Heparinization and Adequate Activated Clotting Time: A Case Report
This case alerts the anesthesiologists of possible thrombus formation despite full heparinization during cardiac surgery and the importance of a comprehensive echocardiography examination.
An Evaluation of Factors Affecting Activated Coagulation Time
All these observations suggest that failure to achieve an adequate ACT is, in general, not an indicator of AT deficiency but could be affected by high platelet counts and low hemoglobin levels.
High Mortality Associated with Intracardiac and Intrapulmonary Thromboses after Cardiopulmonary Bypass
In this retrospective review, we attempt to identify risk factors and propose possible mechanisms of thromboses after cardiopulmonary bypass (CPB).