Mesenchymal Stem Cell Therapy in Osteoarthritis: Advanced Tissue Repair or Intervention with Smouldering Synovial Activation
Desando and co-workers report in Arthritis Research & Therapy that intra-articular delivery of adipose-derived stem cells attenuates progression of synovial activation and joint destruction in osteoarthritis in an experimental rabbit model. Clinical studies are warranted to see whether this approach might be a novel way to combat development of joint destruction in inflammatory subtypes of osteoarthritis.
Decreased Erythrocyte Deformability After Transfusion and the Effects of Erythrocyte Storage Duration
The findings demonstrate that increased duration of erythrocyte storage is associated with decreased cell membrane deformability and that these changes are not readily reversible after transfusion.
Establishing proof of concept: Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate may Improve Cartilage Repair Following Surgical Treatment for Osteochondral Lesions of the Talus
The basic science literature therefore establishes the proof of concept that biological adjuncts may improve cartilage repair when used in conjunction with reparative and replacement treatment strategies for osteochondral lesions of the talus.
Regenerate Augmentation with Bone Marrow Concentrate after Traumatic Bone Loss
The aim of this feasibility study was to investigate the potential of bone marrow aspiration concentrate (BMAC) for percutaneous regenerate augmentation to accelerate bony consolidation of the regenerate.
In Vivo Comparison of the Bone Regeneration Capability of Human Bone Marrow Concentrates vs. Platelet-Rich Plasma
The objective of this study was to evaluate the effects of human BMAC and PRP in combination with β-tricalcium phosphate (β-TCP) on promoting initial bone augmentation in an immunodeficient mouse model.
Outcomes after Ultrasound-Guided Platelet-Rich Plasma Injections for Chronic Tendinopathy: A Multicenter, Retrospective Review
In this retrospective study, in which we evaluated administration of PRP for chronic tendinopathy, we found that the majority of patients reported a moderate (>50%) improvement in pain symptoms.
Platelet Rich Plasma. A New Treatment Tool for the Rheumatologist
In the following review we will analyze in detail its principles, preparation, and management regimes. We will reflect on potential adverse effects and, finally, there will be a critical analysis of the scientific evidence that supports its potential use in the rheumatology clinic.
Platelet Rich Plasma use in Allograft ACL Reconstructions: Two-Year Clinical Results of a MOON Cohort Study
The purpose of this study was to evaluate the effect of intra-operative PRP on patient-reported outcomes 2 years after ACL reconstruction with tibialis anterior allograft.
An Exercise-Based Physical Therapy Program for Patients with Patellar Tendinopathy after Platelet-Rich Plasma Injection
This study extensively describes, based on current knowledge, a physical therapy program after PRP injection for patellar tendinopathy patients.
The Positive Effects of Different platelet-Rich Plasma Methods on Human Muscle, Bone, and Tendon Cells
The primary findings of this study suggest the application of different PRP separations may result in a potential beneficial effect on the clinically relevant target cells in vitro.
Platelet-Rich Plasma Versus Focused Shock Waves in the Treatment of Jumper’s Knee in Athletes
Therapeutic injections of PRP lead to better midterm clinical results compared with focused ESWT in the treatment of jumper's knee in athletes.
Platelet-Rich Plasma (PRP): An Adjuvant to Hasten Hamstring Muscle Recovery. A Randomized Controlled Trial Protocol
This study protocol proposes a rigorous and potential significant evaluation of PRP use for grade-2 hamstring injury.