Modified Ultrafiltration (MUF) Should be Used in Adult CPB (EP Video)
Bob Groom debates the use of modified ultrafiltration during adult CPB (9:00 minutes).
Longevity and Precision of Online Blood Gas Monitoring in Patients with ECMO or Extracorporeal Life Support (EP Video)
Mirko Kaluza discusses his long-term experiences with inline blood gas monitor for ECMO procedures (11:37 minutes).
Cerebral Oximetry Should be a Standard in Adult CPB Surgery (EP Video)
Robert Bakers discusses the logic of why cerebral oximetry should be a gold standard in cardiac surgery (16:29 minutes).
Assessment and Management of Massive Bleeding: Coagulation Assessment, Pharmacologic Strategies, and Transfusion Management
This review details the current knowledge in massive hemorrhage with regard to the pathophysiology and laboratory assessment of the coagulation disturbance, the role of plasma and platelet transfusion, the role of pharmaceutical strategies, and the clinical value of having a massive transfusion protocol.
Immediate Effects of Individualized Heparin and Protamine Management on Hemostatic Activation and Platelet Function in Adult Patients Undergoing Cardiac Surgery with Tranexamic Acid Antifibrinolytic Therapy
This randomized prospective study was initiated to clarify whether individualized heparin and protamine dosing has immediate effects on hemostatic activation and platelet function in adult cardiac surgery.
Antifibrinolytic Agents in Current Anaesthetic Practice
Antifibrinolytic drugs have become almost ubiquitous in their use during major surgery when bleeding is expected or commonplace. Inhibition of the fibrinolytic pathway after tissue injury has been consistently shown to reduce postoperative or traumatic bleeding. We have reviewed the current literature for this increasingly popular class of drugs to support clinical judgement in daily anaesthetic practice.
Influence of Different Tranexamic Acid Administration Methods during and after Cardiac Surgery on Coagulation Function and Postoperative Blood Loss
This study evaluates the influence of different tranexamic acid administration methods during and after cardiac surgery with cardiopulmonary bypass(CPB) on coagulation function and postoperative bleeding.
Antifibrinolytics in Cardiac Surgery
Cardiac surgery exerts a significant strain on the blood bank services and is a model example in which a multi-modal blood-conservation strategy is recommended.
Management of Massive Bleeding in 2013: Seven Questions and Answers
The management of massive bleeding has improved, thanks to high-quality blood components and new transfusion strategies. However, it remains controversial and, despite a huge body of literature, randomised control trials are still lacking.
Platelet Concentrates, from Whole Blood or Collected by Apheresis
The quality and characteristics of platelets during storage are affected by a number of factors, such as anticoagulant, centrifugation and processing after collection, and pre- or post storage pooling, but when comparing literature on the various methods, most differences balance out.
Low Hemorrhage-Related Mortality in Trauma Patients in a Level I Trauma Center Employing Transfusion Packages and Early Thromboelastography-Directed Hemostatic Resuscitation with Plasma and Platelets
This was a prospective study of adult trauma patients admitted to a Level I trauma center. Demography, Injury Severity Score (ISS), transfusion therapy, and mortality were registered. Hemostatic resuscitation was based on a massive transfusion protocolencompassing transfusion packages and thromboelastography (TEG)-guided therapy.
Tranexamic Acid in Remote Damage Control Resuscitation
In this paper, the authors review the current state of the art for tranexamic acid (TXA) and its potential benefits to those patients who are in need of a massive transfusion. Specifically addressed are its biologic and pharmacologic properties, as well the results of a number of recent studies.