Patient Blood Management – The New Frontier
As one of the oldest and most common procedures in clinical practice, allogeneic blood transfusions face many issues including questionable safety and efficacy, increasing costs and limited supply.
The Approach to Patients with Bleeding Disorders Who Do Not Accept Blood-Derived Products
Despite the widespread use of allogeneic blood components in clinical practice, there are patients in whom transfusion cannot be carried out for various reasons, including refusal of transfusions because of religious beliefs.
Should Jehovah’s Witness Patients be Listed for Heart Transplantation
This best evidence topic in Cardiac Surgery was written according to a structured protocol. The question addressed was: for [Jehovah's Witness patients with end-stage heart failure] can these patients undergo a [heart transplantation] without an increased rate of mortality.
A Novel Method for the Direct Determination of Heparin Concentration During Cardiopulmonary Bypass Surgery
The aim of this prospective study was to test a novel light scattering assay (LiSA) for the direct determination of heparin concentration during cardiopulmonary bypass (CPB) surgery and to compare the heparin concentrations with routinely determined activated clotting time (ACT).
Voluven, A New Colloid Solution
As the Voluven molecule is smaller than those of other available hydroxyethyl starch products, it is associated with less plasma accumulation and can be safely used in patients with renal impairment.
Crystalloids VS. Colloids: KO at the Twelfth Round
We conducted a large-scale randomized controlled trial to evaluate the safety and efficacy of 6% hydroxyethyl starch (HES) (130/0.4) in 0.9% saline as compared with 0.9% saline alone for fluid resuscitation in a heterogeneous population of adult patients in the ICU.
Effect of the Colloids Gelatin and HES 130/0.4 on Blood Coagulation in Cardiac Surgery Patients: A Randomized Controlled Trial
The aim of this study was to investigate the effect of synthetic colloids on blood loss and blood coagulation in patients after on-pump coronary artery bypass graft (CABG) procedures.
Albumin Utilization in Cardiac Surgery after Transition to Hydroxyethyl Starch 130/0.4
This study evaluated the impact of replacing hydroxyethyl starch (HES) 670/0.75 with lower molecular weight HES 130/0.4 on albumin utilization in cardiac surgery, as well as any impact on renal function and bleeding.
Development of a Cost-Effective Method for Platelet-Rich Plasma (PRP) Preparation for Topical Wound Healing
Costs were shown to be lower than those of other methods which require specific equipment and high-cost disposables, while safety and traceability can be increased.
The Systemic Effects of Platelet-Rich Plasma Injection
The objective for this study is too quantify the effect of PRP injection on systemic growth factors with performance-enhancing effects and to identify molecular markers to detect treated athletes.
Exercise and the Platelet Activator Calcium Chloride both Influence the Growth Factor Content of Platelet-Rich Plasma (PRP): Overlooked Biochemical Factors that Could Influence PRP Treatment
The first aim of this study was to evaluate the effect of exercise on platelet and platelet-derived growth factors (PDGF)-AB, hepatocyte growth factor (HGF), insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) concentrations in PRP. The second aim was to study the effect of the activating agent calcium chloride (CaCl2) on growth factor concentration in relation to different exercise states.
The Combined Use of Transmyocardial Laser Revascularisation and Intramyocardial Injection of Bone-Marrow Derived Stem Cells in Patients with End-Stage Coronary Artery Disease: One Year Follow-Up
There are a growing number of patients with end-stage coronary artery disease (CAD) and refractory angina. Angiogenesis may be induced by intramyocardial injection of autologous bone marrow stem cells, intensified by inflammationaround channels performed by laser.