Is There a “Blind Spot” in Point-of-Care Testing for Residual Heparin After Cardiopulmonary Bypass? A Prospective, Observational Cohort Study
This difference suggests that an interference in the detection of residual heparinization with point-of-care methods exists right after the application of protamine, which seems to subside after a short time span.
Patient Blood Management: The Best Approach to Transfusion Medicine Risk Management
In an effort to maximise patient safety, transfusion medicine practice culture needs to shift towards a patient blood management approach, with hospitals implementing it as an important tool to minimize the risks of allogeneic blood transfusion.
A Canadian Perspective on The Use and Preparation of Cryopreserved Red Cell Concentrates
This method produces units that meet all Canadian regulatory standards. Introduction of extended outdates has allowed CBS to decrease operational costs and improve cryopreserved RCC product quality.
Preoperative Anemia Correction in Cardiac Surgery: A Propensity-Matched Study
Anemia correction before cardiac surgery is associated with a reduction in both the RBC transfusion rate and the amount of units transfused.
Building A Patient Blood Management Program in A Large-Volume Tertiary Hospital Setting: Problems and Solutions
In this review, we aimed to share previous experiences and indicate current problems with solutions which would ensure the implementation of a PBM protocol in our hospital that can be also a guide for similar large-volume tertiary hospitals.
Impact of Patient Blood Management Guidelines on Blood Transfusions and Patient Outcomes During Cardiac Surgery
Following the publication of the guidelines, there was a measurable reduction in perioperative blood transfusions in cardiac surgery with an associated reduction in hospital length of stay but no detectable differences in other patient outcomes.
Extensive Cell Salvage and Postoperative Outcomes Following Thoracoabdominal and Descending Aortic Repair
Increased salvaged cell units were associated with adverse postoperative outcomes after D/TAAA repairs. Risk of renal failure and mortality increased proportionally to the salvaged cell units.
Perioperative Management for Patients with von Willebrand Disease: Defining the Optimal Approach
This review provides an overview of the current evidence for the surgical management of patients with VWD and, summarises the optimal treatment approach during the perioperative period
A European Consensus Statement on The Use of Four-Factor Prothrombin Complex Concentrate for Cardiac and Non-Cardiac Surgical Patients
Tissue‐factor‐activated, factor VII‐dependent and heparin insensitive point‐of‐care tests may be used for peri‐operative monitoring and guiding of prothrombin complex concentrate therapy.
Therapeutic Potential of Fibrinogen Γ-Chain Peptide-Coated, ADP-Encapsulated Liposomes as A Haemostatic Adjuvant for Post-Cardiopulmonary Bypass Coagulopathy
These findings suggest that H12-ADP-liposomes could help effectively and safely consolidate platelet haemostasis in post-CPB coagulopathy and may have potential for reducing bleeding complications after cardiovascular surgery with CPB.
Multiple Electrode Aggregometry After Cardiopulmonary Bypass to Assess Platelet (Dys)-Function and Transfusion Threshold: A Concordance Study
The application of new Multiplate analyzer technologies, like the ADP test, have the potential to reduce platelet transfusion rates in cardiac surgery patients compared with the use of platelet counts alone; this point-of-care test may constitute an important strategy to help spare the use of allogeneic blood products. Additional studies are needed to confirm this trend and establish the best cutoff values to apply.
Intravenous Iron Therapy for Patients with Preoperative Iron Deficiency or Anaemia Undergoing Cardiac Surgery Reduces Blood Transfusions: A Systematic Review and Meta-Analysis
This meta-analysis suggests that IV iron improves postoperative morbidity in adult cardiac surgery patients with preoperative anaemia or iron deficiency. A large, rigorous, placebo-controlled, double-blinded, multicentre trial is needed to clarify the role of IV iron in this patient population.