A Randomized Controlled Trial of Antithrombin Supplementation During Extracorporeal Membrane Oxygenation
Antithrombin supplementation may not decrease heparin requirement nor diminish the incidence of bleeding and/or thrombosis in adult patients on venovenous extracorporeal membrane oxygenation.
Clinical Controversies in Anticoagulation Monitoring and Antithrombin Supplementation for ECMO
In this clinically focused review, the authors discuss the complexities of anticoagulation monitoring and therapeutic intervention for patients on ECMO and examine the challenges surrounding AT supplementation given both the historical and current perspectives summarized in the literature on these topics.
Clotting Functional Stability of Withdrawing Blood in Storage for Acute Normovolemic Hemodilution: A Pilot Study
Even though the MCE significantly decreased in a time-dependent manner, MCF of FIBTEM and EXTEM was normal up to 24 h storage. The blood of ANH can use for the purpose of hemostasis at least 8 h stored at room temperature after blood withdrawal.
Low Antithrombin Levels in Neonates and Infants Undergoing Congenital Heart Surgery Result in More Red Blood Cell and Plasma Transfusion on Cardiopulmonary Bypass
Low preoperative AT level is associated with increased transfusion of RBC and FFP on CPB in neonates and infants undergoing congenital heart surgery. Low preoperative AT level did not result in coagulation activation after CPB and after surgery.
Rapid Thrombelastography Predicts Perioperative Massive Blood Transfusion in Patients Undergoing Coronary Artery Bypass Grafting: A Retrospective Study
Preoperative r-TEG activated clotting time can predict the increase of postoperative MBT in patients undergoing CABG. We recommend the careful monitoring of coagulation system with r-TEG, which allows rapid diagnosis of coagulation abnormalities even before the start of surgery.
Risk Factors Associated with Difficult Reversal of Heparin by Protamine Sulfate in Cardiopulmonary Bypass: An Ignored Issue
Surgeons’ efforts to reduce operative time and avoid deep hypothermia may be helpful for increasing the likelihood of easy heparin reversal, especially in female patients.
Massive Blood Loss Protocol ‘Code Red’ At Papworth Hospital: A Closed Loop Audit
Preparation for and anticipation of massive blood loss has likely decreased the number of incidences requiring ‘Code Red’ activation, permitting delivery of safe patient care.
Factors Associated with Errors in The Heparin Dose Response Test: Recommendations to Improve Individualized Heparin Management in Cardiopulmonary Bypass
Based on our analysis, we provide several recommendations and a flow chart to improve the quality of individualized heparin management on CPB.
Transfusion in Elective Aortic Root Replacement: Analysis of the STS Adult Cardiac Surgery Database
Elective aortic root replacement can be performed with acceptable requirements for blood products. Composite root replacement has a greater likelihood of transfusion than does a valve-sparing procedure.
A Comparative Analysis of Four Activated Clotting Time Measurement Devices in Cardiac Surgery with Cardiopulmonary Bypass
Careful validation must be undertaken when adopting a different method as decision limits would be affected. Clinicians should also be cautious using ACT as the only indicator for full heparin reversal.
Factors Associated with Errors in The Heparin Dose Response Test: Recommendations to Improve Individualized Heparin Management in Cardiopulmonary Bypass
The mACT can be substantially different from eACT. The accuracy of the HDR test appears to be dependent upon bACT, slope, and CHC. Based on our analysis, we provide several recommendations and a flow chart to improve the quality of individualized heparin management on CPB.
Limited Effect of Red Blood Cell Transfusion on Long-Term Mortality Among Anaemic Cardiac Surgery Patients
No statistically significant association between RBC transfusion and long-term mortality was found when we adjusted for known risk factors. This study suggests that the observed difference in mortality in this patient group is largely due to patient-related risk factors.