Does Blood Transfusion Harm Cardiac Surgery Patients?
Over recent years there has been a substantial body of evidence demonstrating strong associations between transfusion and adverse outcomes, including myocardial, neurological and renal injury, in a range of clinical settings where transfusion is administered for reasons other than life-threatening bleeding.
Impact of Fresh-Frozen Plasma from Male-Only Donors Versus Mixed-Sex Donors on Postoperative Respiratory Function in Surgical Patients: A Prospective Case-Control Study
: This study compared pulmonary function after the transfusion of FFP derived from either male donors only (FFP-male) or mixed donors (FFP-mixed) in informed surgical patients treated at a tertiary university hospital in Japan.
Efficacy and Cost-Effectiveness of Cell Saving Blood Autotransfusion in Adult Lumbar Fusion
The objective of this study was to explore the use of cell saver blood autotransfusion in spinal surgery and to evaluate the efficacy and cost-effectiveness of cell saver blood autotransfusion during lumbar spine fusion in adults.
Mortality In Trauma Patients May Be Doubled By Old Red Blood Cells
Severe trauma patients requiring a major transfusion are twice as likely to die if they receive red blood cells stored for a month or longer, according to research published in BioMed Central's open access journal Critical Care.
Lepirudin in the Management of Patients With Heparin-Induced Thrombocytopenia
Lepirudin, a recombinant hirudin, is a direct irreversible thrombin inhibitor by binding to both free and clot-bound thrombin.
Clinical Efficacy of Two-Phase Leukocyte Filtration in High-Risk Patients Undergoing Coronary Revascularization with Cardiopulmonary Bypass
The purpose of this study was to investigate the clinical outcome, inflammatory response and myocardial function in high-risk patients undergoing three different leukocyte depletion strategies.
Soluble Fibrin Monomer Complex and Cardiopulmonary Bypass
The purpose of this study was to determine whether a positive SFMC test is associated with pre-operative, intra-operative, and post-operative variables for patients that have undergone cardiopulmonary bypass (CPB).
Blood Utilization at a Level I Trauma Center: Is This as Good as it Gets?
Recognition of the adverse effects of allogeneic blood resulted in the decreased use of red blood cell (RBC) transfusion in surgical practice in the 1990s.
Perioperative Handling of Patients on Antiplatelet Therapy with Need for Surgery
The widespread use of metal stents and drug-eluting stents has shown the extent to which patients with unstable coronary perfusion depend on antiplatelet drugs, and how their risk of late thrombosis depends on the long-term use of agents such as clopidogrel.
ZymoGenetics Submits Citizen Petition to FDA Requesting Removal of Bovine Thrombin from Market in the Interest of Patient Safety
ZymoGenetics, Inc. (NASDAQ:ZGEN), announced today the submission of a Citizen Petition to the U.S. Food and Drug Administration (FDA) requesting that the FDA remove Thrombin-JMI® Thrombin, topical (bovine origin) from the market in the interest of patient safety. The Citizen Petition is prompted by recent reports of serious or fatal bleeding-related adverse events in surgical patients exposed to bovine (cattle-derived) thrombin.
Relationships Among Haemoglobin Level, Packed Red Cell Transfusion and Clinical Outcomes in Patients After Cardiac Surgery
To identify associations among haemoglobin (Hb) concentrations, blood transfusions, and clinical outcomes in patients after cardiac surgery, especially in those who undergo valve replacement or bypass surgery.